The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort

Cheng, Wenjuan, Wen, Shiling, Wang, Yutang, Qian, Zhiping, Tan, Yuyao, Li, Honying, Hou, Yueli, Hu, Haiyang, Golledge, Jonathan, and Yang, Guang (2017) The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort. Medicine, 96 (50).

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Abstract

High serum uric acid (sUA) has been reported to be a risk factor for hypertension however, whether this is the case for all age groups is not clear. We examined the association between sUA concentrations and systolic and diastolic blood pressure (SBP and DBP) in different age groups in a cohort of healthy Chinese participants. A total of 1082 healthy participants aged from 41 to 70 years were included. sUA concentration was measured by the uricaseperoxidase method. SBP and DBP were assessed using mercury sphygmomanometry. Hypertension was defined as SBP ≥140 mm Hg or DBP ≥90 mm Hg. Hyperuricemia (HUA) was defined as sUA concentration of >7mg/dL in men and >6mg/dL in women. The association between sUA concentration and SBP and DBP was examined using Pearson's correlation test, multivariate linear regression, and logistic regression analysis.

The prevalence of hypertension and HUA increased with age (P<.001). Hypertension was more common in participants that had HUA than in those that did not (38.95% vs 30.16%, P=.02). Higher sUA was significantly associated with higher SBP and DBP in the 41- to 50-year-old participants (SBP, b=0.35, P<.001; DBP, b=.29, P<.001; after adjustment for age, sex, total cholesterol, estimated glomerular filtration rate, and fasting plasma glucose). HUA was also a risk factor for hypertension in this age group (odds ratio 1.425, 95% confidence interval, 1.217–1.668, P<.001). There was no association between sUA concentration and SBP and DBP in the other age groups.

In this population of healthy Chinese participants, sUA concentration was positively associated with hypertension only in the 41- to 50-year-old group. Lowering uric acid in this age group may help to reduce the incidence of hypertension.

Item ID: 52950
Item Type: Article (Research - C1)
ISSN: 1536-5964
Keywords: serum uric acid, hyperuricemia, blood pressure, hypertension
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© 2017 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Date Deposited: 28 Mar 2018 03:14
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110399 Clinical Sciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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