Techniques and technologies for the biodiscovery of novel small molecule drug lead compounds from natural products

Wangchuk, Phurpa, and Loukas, Alex (2018) Techniques and technologies for the biodiscovery of novel small molecule drug lead compounds from natural products. In: Mandal, Subhash C., Mandal, Vivekananda, and Konishi, Tetsuya, (eds.) Natural Products and Drug Discovery: An Integrated Approach. Elsevier, Amsterdam, Netherlands, pp. 435-465.

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Natural resources including plants, animals and microorganisms contain enormous chemical diversity with huge potential for therapeutic applications. Identifying new drug lead compounds from these sources, which is the first critical stage of the drug development process, is a demanding task requiring multi-disciplinary approaches including material identification, collection, extraction, isolation, purification, characterisation, structure elucidation, identification, biological activity screening, lead optimisation, and pre-clinical evaluation in animal models. To support all these stages of drug lead identification, life science manufacturers have developed large numbers of powerful tools and technologies that have led to new paradigms in high-throughput drug discovery. Our chapter will focus on this first critical stage of drug discovery – identification of drug lead compounds from natural sources. We present the techniques and technologies currently available to screen bioactive natural products within the so-called “metabolomics” field.

Item ID: 52944
Item Type: Book Chapter (Research - B1)
ISBN: 978-0-08-102081-4
Keywords: drug lead identification; metabolomics; natural products; techniques; technologies
Date Deposited: 17 Apr 2018 03:50
FoR Codes: 34 CHEMICAL SCIENCES > 3404 Medicinal and biomolecular chemistry > 340401 Biologically active molecules @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320501 Medical biochemistry - amino acids and metabolites @ 30%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321405 Pharmaceutical sciences @ 30%
SEO Codes: 92 HEALTH > 9202 Health and Support Services > 920299 Health and Support Services not elsewhere classified @ 20%
97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 40%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 40%
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