Editorial: Inflammation in the CNS: advancing the field using intravital imaging

Pai, Saparna, Hickey, Michael J., and Weninger, Wolfgang (2017) Editorial: Inflammation in the CNS: advancing the field using intravital imaging. Frontiers in Immunology, 8. 1155.

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Abstract

[Extract] Inflammation of the central nervous system (CNS) contributes to a diverse array of life-threatening and debilitating conditions. These include autoimmune conditions such as multiple sclerosis (MS), progressive degenerative conditions [Alzheimer’s disease (AD)], sterile inflammation as occurs in stroke/cerebral ischaemia, and inflammation stemming from parasitic, fungal, viral, and bacterial infections. Whilst recent developments have led to improved outcomes in some of these conditions, most notably MS (1), there remains concerns with these approaches (2). Furthermore, there is an increasing prevalence of AD and stroke among the ageing population in the developed world, whilst in sub-Saharan Africa, cerebral malaria remains a major cause of mortality. These factors mandate a greater understanding of the inflammatory mechanisms in the CNS associated with these conditions. As is the case with all inflammation, inflammatory responses in the CNS involve immune cell entry/migration, complex interplay between resident and circulating immune cells, parenchymal cells, the cellular constituents of the CNS microvasculature, and alterations in immune cell function.

Item ID: 52930
Item Type: Article (Editorial)
ISSN: 1664-8714
Keywords: intravital imaging; leucocytes; inflammation; brain; central nervous system disorders
Date Deposited: 11 Apr 2018 05:13
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110707 Innate Immunity @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 40%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 40%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 20%
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