Acute rheumatic fever and rheumatic heart disease

McDonald, Malcolm (2018) Acute rheumatic fever and rheumatic heart disease. In: UNSPECIFIED, (ed.) National guide to a preventive health assessment for Aboriginal and Torres Strait Islander people: Evidence base. Royal Australian College of Physicians, Melbourne, VIC, Australia, pp. 213-222.

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[Extract] ‘While acute rheumatic fever has become a rare curiosity in Australia’s non-Indigenous population, its incidence in Indigenous Australians living in remote areas remains among the highest reported in the world. It is unlikely that such a stark contrast between two populations living within the same national borders exists for any other disease or on any other continent.’1 Acute rheumatic fever (ARF) is an illness caused by an abnormal and exaggerated immune response to infection with Group A beta-haemolytic streptococcus (GAS or Streptococcus pyogenes). The role of preceding GAS throat infection is undisputed, although preceding symptomatic GAS pharyngitis is infrequently identified in Aboriginal and Torres Strait Islander populations.2 The role of preceding skin infection in ARF is less certain.3 Immune priming is possibly important but the exact pathogenic mechanisms remain elusive.4,5

Item ID: 52879
Item Type: Book Chapter (Research - B1)
ISBN: 978-0-86906-485-6
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Copyright Information: © The Royal Australian College of General Practitioners 2018
Date Deposited: 11 Mar 2018 22:57
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 50%
92 HEALTH > 9203 Indigenous Health > 920302 Aboriginal and Torres Strait Islander Health - Health Status and Outcomes @ 50%
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