Acute rheumatic fever and rheumatic heart disease

McDonald, Malcolm (2018) Acute rheumatic fever and rheumatic heart disease. In: UNSPECIFIED, (ed.) National guide to a preventive health assessment for Aboriginal and Torres Strait Islander people: Evidence base. Royal Australian College of Physicians, Melbourne, VIC, Australia, pp. 213-222. (In Press)

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'While acute rheumatic fever has become a rare curiosity in Australia’s non-Indigenous population, its incidence in Indigenous Australians living in remote areas remains among the highest reported in the world. It is unlikely that such a stark contrast between two populations living within the same national borders exists for any other disease or on any other continent.’ ¹Acute rheumatic fever (ARF) is an illness caused by an abnormal and exaggerated immune response to infection with Group A beta-haemolytic streptococcus (GAS or Streptococcus pyogenes). The role of preceding GAS throat infection is undisputed, although preceding symptomatic GAS pharyngitis is infrequently identified in Aboriginal and Torres Strait Islander populations. ² The role of preceding skin infection in ARF is less certain. ³ Immune priming is possibly important but the exact pathogenic mechanisms remain elusive. ⁴⁵

Item ID: 52879
Item Type: Book Chapter (Research - B1)
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Copyright Information: © The Royal Australian College of General Practitioners 2018
Date Deposited: 11 Mar 2018 22:57
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 50%
92 HEALTH > 9203 Indigenous Health > 920302 Aboriginal and Torres Strait Islander Health - Health Status and Outcomes @ 50%
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