Acute rheumatic fever and rheumatic heart disease

McDonald, Malcolm (2018) Acute rheumatic fever and rheumatic heart disease. In: Royal Australian College of General Practitioners, , (ed.) National Guide to a Preventive Health Assessment for Aboriginal and Torres Strait Islander People, 3rd edition. Royal Australian College of Physicians, Melbourne, VIC, Australia. (In Press)

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Abstract

'While acute rheumatic fever has become a rare curiosity in Australia’s non-Indigenous population, its incidence in Indigenous Australians living in remote areas remains among the highest reported in the world. It is unlikely that such a stark contrast between two populations living within the same national borders exists for any other disease or on any other continent.’ ¹Acute rheumatic fever (ARF) is an illness caused by an abnormal and exaggerated immune response to infection with Group A beta-haemolytic streptococcus (GAS or Streptococcus pyogenes). The role of preceding GAS throat infection is undisputed, although preceding symptomatic GAS pharyngitis is infrequently identified in Aboriginal and Torres Strait Islander populations. ² The role of preceding skin infection in ARF is less certain. ³ Immune priming is possibly important but the exact pathogenic mechanisms remain elusive. ⁴⁵

Item ID: 52879
Item Type: Book Chapter (Research - B1)
Date Deposited: 11 Mar 2018 22:57
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 50%
92 HEALTH > 9203 Indigenous Health > 920302 Aboriginal and Torres Strait Islander Health - Health Status and Outcomes @ 50%
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