HTR2A gene variation is involved in antidepressant treatment response

Lucae, Susanne, Ising, Marcus, Horstmann, Sonja, Baune, Bernhard T., Arolt, Volker, Muller-Myhsok, Bertram, Holsboer, Florian, and Domschke, Katharina (2010) HTR2A gene variation is involved in antidepressant treatment response. European Neuropsychopharmacology, 20 (1). pp. 65-68.

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Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STAR*D (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STAR*D sample.

Item ID: 5271
Item Type: Article (Research - C1)
ISSN: 1873-7862
Keywords: HTR2A; pharmacogenetics; SNP; treatment response; major depression; association study
Date Deposited: 07 Feb 2010 23:53
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
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