Malingered psychotic symptoms and quetiapine abuse in a forensic setting

Caniato, Riccardo N., Gundabawady, Anand, Baune, Bernhard T., and Alvarenga, Marlies E. (2009) Malingered psychotic symptoms and quetiapine abuse in a forensic setting. Journal of Forensic Psychiatry and Psychology, 20 (6). pp. 928-935.

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Quetiapine is an antipsychotic drug whose effect appears to be mediated through antagonist activity at the dopamine and serotonin receptors. While Quetiapine is not currently classified as a controlled substance, there have been a growing number of reports of the drug being abused both in American prisons and in general community settings. These accounts have included reports of both intranasal and intravenous uses. In this paper we report two cases of prisoners deliberately feigning psychotic symptoms for the purposes of obtaining quetiapine. In both cases there appears to be some evidence of psychological dependence and of a discontinuation syndrome when the medication was ceased. Our report adds support to the possibility that quetiapine has clinically relevant reinforcing properties with potential for producing both dependence and withdrawal symptoms and as such it should be re-evaluated as a drug with addictive potential and abuse risk.

Item ID: 5267
Item Type: Article (Research - C1)
ISSN: 1478-9957
Keywords: forensic psychiatry; malingering; specialist substance misuse training; psychotic symptoms
Date Deposited: 18 Apr 2010 23:07
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
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