Clinical relevance of a p value: Does tranexamic acid save lives after trauma or postpartum hemorrhage?

Dobson, Geoffrey P., Doma, Kenji, and Letson, Hayley L. (2018) Clinical relevance of a p value: Does tranexamic acid save lives after trauma or postpartum hemorrhage? Journal of Trauma and Acute Care Surgery, 84 (3). pp. 532-536.

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Abstract

[Extract] Tranexamic acid (TXA), an antifibrinolytic agent, has been widely publicized as saving lives after traumatic hemorrhage in the CRASH-2, MSATTERs, and PER-TRAX trials (2-5) and more recently after postpartum hemorrhage (PPH) in the World Maternal Antifibrinolytic (WOMAN) trial (6). Prophylactic administration of TXA is also increasingly used in major elective and emergency surgery to reduce excessive bleeding, transfusion requirements, and possible reexploration. (7)

Item ID: 52643
Item Type: Article (Commentary)
ISSN: 2163-0763
Keywords: haemorrhage; post-partum; tranexamic acid; bleeding; clinical; statistical significance; confidence intervals
Date Deposited: 22 Feb 2018 03:22
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110305 Emergency Medicine @ 5%
11 MEDICAL AND HEALTH SCIENCES > 1114 Paediatrics and Reproductive Medicine > 111402 Obstetrics and Gynaecology @ 10%
11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 85%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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