Mission accomplished? We need a guide to the ‘post release’ world of Wolbachia for Aedes-borne disease control

Ritchie, Scott A., van den Hurk, Andrew F., Smout, Michael J., Staunton, Kyran M., and Hoffmann, Ary A. (2018) Mission accomplished? We need a guide to the ‘post release’ world of Wolbachia for Aedes-borne disease control. Trends in Parasitology, 34 (3). pp. 217-226.

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Abstract

Historically, sustained control of Aedes aegypti, the vector of dengue, chikungunya, yellow fever, and Zika viruses, has been largely ineffective. Subsequently, two novel ‘rear and release’ control strategies utilizing mosquitoes infected with Wolbachia are currently being developed and deployed widely. In the incompatible insect technique, male Aedes mosquitoes, infected with Wolbachia, suppress populations through unproductive mating. In the transinfection strategy, both male and female Wolbachia-infected Ae. aegypti mosquitoes rapidly infect the wild population with Wolbachia, blocking virus transmission. It is critical to monitor the long-term stability of Wolbachia in host populations, and also the ability of this bacterium to continually inhibit virus transmission. Ongoing release and monitoring programs must be future-proofed should political support weaken when these vectors are successfully controlled.

Item ID: 52280
Item Type: Article (Research - C1)
ISSN: 1471-5007
Keywords: Wolbachia; Aedes aegypti; dengue virus; Zika virus; transinfection; sterile insect technique
Date Deposited: 28 Mar 2018 00:23
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 100%
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