Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the international collaboration of Endocarditis-Prospective Cohort Study

Chirouze, C., Alla, F., Fowler, V.G., Sexton, D.J., Corey, G.R., Chu, V.H., Wang, A., Erpelding, M.-L., Durante-Mangoni, E., Fernandez-Hidalgo, N., Giannitsioti, E., Hannan, M.M., Lejko-Zupanc, T., Miro, J.M., Munoz, P., Murdoch, D.R., Tattevin, P., Tribouilloy, C., Hoen, B., Clara, L., Sanchez, M., Nacinovich, F., Oses, P.F., Ronderos, R., Sucari, A., Thierer, J., Casabe, J., Cortes, C., Altclas, J., Kogan, S., Spelman, D., Athan, E., Harris, O., Kennedy, K., Tan, R., Gordon, D., Papanicolas, L., Eisen, Damon, Grigg, L., Street, A., Korman, T., Kotsanas, D., Dever, R., Jones, P., Konecny, P., Lawrence, R., Rees, D., Ryan, S., Feneley, M.P., Harkness, J., Jones, P., Ryan, S., Jones, P., Ryan, S., Jones, P., Post, J., Reinbott, P., Ryan, S., Gattringer, R., Wiesbauer, F., Andrade, A.R., de Brito, A.C.P., Guimaraes, A.C., Grinberg, M., Mansur, A.J., Siciliano, R.F., Strabelli, T.M.V., Vieira, M.L.C., de Medeiros Tranchesi, R.A., Paiva, M.G., Fortes, C.Q., de Oliveira Ramos, A., Ferraiuoli, G., Golebiovski, W., Lamas, C., Santos, M., Weksler, C., Karlowsky, J.A., Keynan, Y., Morris, A.M., Rubinstein, E., Jones, S.B., Garcia, P., Cereceda, M., Fica, A., Mella, R.M., Barsic, B., Bukovski, S., Krajinovic, V., Pangercic, A., Rudez, I., Vincelj, J., Freiberger, T., Pol, J., Zaloudikova, B., Ashour, Z., El Kholy, A., Mishaal, M., Rizk, H., Aissa, N., Alauzet, C., Alla, F., Campagnac, C., Doco-Lecompte, T., Selton-Suty, C., Casalta, J.-P., Fournier, P.-E., Habib, G., Raoult, D., Thuny, F., Delahaye, F., Delahaye, A., Vandenesch, F., Donal, E., Donnio, P.Y., Michelet, C., Revest, M., Tattevin, P., Violette, J., Chevalier, F., Jeu, A., Sorel, C., Tribouilloy, C., Bernard, Y., Chirouze, C., Hoen, B., Leroy, J., Plesiat, P., Naber, C., Neuerburg, C., Mazaheri, B., Naber, C., Neuerburg, C., Athanasia, S., Giannitsioti, E., Mylona, E., Paniara, O., Papanicolaou, K., Pyros, J., Skoutelis, A., Sharma, G., Francis, J., Nair, L., Thomas, V., Venugopal, K., Hannan, M., Hurley, J., Gilon, D., Israel, S., Korem, M., Strahilevitz, J., Rubinstein, E., Strahilevitz, J., Casillo, R., Cuccurullo, S., Dialetto, G., Durante-Mangoni, E., Irene, M., Ragone, E., Tripodi, M.F., Utili, R., Cecchi, E., De Rosa, F., Forno, D., Imazio, M., Trinchero, R., Tebini, A., Grossi, P., Lattanzio, M., Toniolo, A., Goglio, A., Raglio, A., Ravasio, V., Rizzi, M., Suter, F., Carosi, G., Magri, S., Signorini, L., Baban, T., Kanafani, Z., Kanj, S.S., Yasmine, M., Abidin, I., Tamin, S.S., Martinez, E.R., Soto Nieto, G.I., van der Meer, J.T.M., Chambers, S., Holland, D., Morris, A., Raymond, N., Read, K., Murdoch, D.R., Dragulescu, S., Ionac, A., Mornos, C., Butkevich, O.M., Chipigina, N., Kirill, O., Vadim, K., Vinogradova, T., Edathodu, J., Halim, M., Lum, L.-N., Tan, R.-S., Lejko-Zupanc, T., Logar, M., Mueller-Premru, M., Commerford, P., Commerford, A., Deetlefs, E., Hansa, C., Ntsekhe, M., Almela, M., Armero, Y., Azqueta, M., Castaneda, X., Cervera, C., del Rio, A., Falces, C., Garcia-de-la-Maria, C., Fita, G., Gatell, J.M., Marco, F., Mestres, C.A., Miro, J.M., Moreno, A., Ninot, S., Pare, C., Pericas, J., Ramirez, J., Rovira, I., Sitges, M., Anguera, I., Font, B., Guma, J.R., Bermejo, J., Bouza, E., Fernandez, M.A.G., Gonzalez-Ramallo, V., Marin, M., Munoz, P., Pedromingo, M., Roda, J., Rodriguez-Creixems, M., Solis, J., Almirante, B., Fernandez-Hidalgo, N., Tornos, P., de Alarcon, A., Parra, R., Alestig, E., Johansson, M., Olaison, L., Snygg-Martin, U., Pachirat, O., Pachirat, P., Pussadhamma, B., Senthong, V., Casey, A., Elliott, T., Lambert, P., Watkin, R., Eyton, C., Klein, J.L., Bradley, S., Kauffman, C., Bedimo, R., Chu, V.H., Corey, G.R., Crowley, A.L., Douglas, P., Drew, L., Fowler, V.G., Holland, T., Lalani, T., Mudrick, D., Samad, Z., Sexton, D., Stryjewski, M., Wang, A., Woods, C.W., Lerakis, S., Cantey, R., Steed, L., Wray, D., Dickerman, S.A., Bonilla, H., DiPersio, J., Salstrom, S.-J., Baddley, J., Patel, M., Peterson, G., Stancoven, A., Afonso, L., Kulman, T., Levine, D., Rybak, M., Cabell, C.H., Baloch, K., Chu, V.H., Corey, G.R., Dixon, C.C., Fowler, V.G., Harding, T., Jones-Richmond, M., Pappas, P., Park, L.P., Redick, T., Stafford, J., Anstrom, K., Athan, E., Bayer, A.S., Cabell, C.H., Chu, V.H., Corey, G.R., Fowler, V.G., Hoen, B., Karchmer, A.W., Miro, J.M., Murdoch, D.R., Sexton, D.J., Wang, A., Bayer, A.S., Cabell, C.H., Chu, V., Corey, G.R., Durack, D.T., Eykyn, S., Fowler, V.G., Hoen, B., Miro, J.M., Moreillon, P., Olaison, L., Raoult, D., Rubinstein, E., and Sexton, D.J. (2015) Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the international collaboration of Endocarditis-Prospective Cohort Study. Clinical Infectious Diseases, 60 (5). pp. 741-749.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: http://doi.org/10.1093/cid/ciu871
 
46
2


Abstract

Background. The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis–Prospective Cohort Study.

Methods. Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use.

Results. EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non–S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39–1.15]; P = .15).

Conclusions. In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE.

Item ID: 52197
Item Type: Article (Research - C1)
ISSN: 1537-6591
Additional Information:

Processed as a priority for ERA 2018, external authors have not had affiliations entered.

Funders: Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Spanish Network for Research in Infectious Diseases (REIPI), Fondo de Investigaciones Sanitarias (FIS), Fundación Máximo Soriano Jiménez
Projects and Grants: REIPI RD06/0008, FIS 1101131
Date Deposited: 30 Jan 2018 01:30
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
Downloads: Total: 2
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page