HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort

Chambers, Stephen T., Murdoch, David, Morris, Arthur, Holland, David, Pappas, Paul, Almela, Manel, Fernández-Hidalgo, Nuria, Almirante, Benito, Bouza, Emilio, Forno, Davide, Rio, Ana del, Hannan, Margaret M., Harkness, John, Kanafani, Zeina A., Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinogradova, Tatiana, Woods, Christopher W., Wray, Dannah, Corey, G. Ralph, Chu, Vivian H., and ICE-PCS Investigators*, (2013) HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort. PLoS ONE, 8 (5). e63181.

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The HACEK group of bacteria (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are a small, heterogeneous group of fastidious, gram-negative bacteria that frequently colonize the oropharynx and have long been recognised as a cause of infective endocarditis (IE). These organisms have been historically reported as causing infection in <5% of patients of IE [1], [2], and 0.8–6% of patients in recent population-based studies [3]–[5].

Due to the relative rarity of HACEK endocarditis (HE), the clinical description and outcome has, of necessity, been derived from compilation of data from small case series and case reports [6]–[10]. These reports are limited by non-standardized data collection and selective reporting of patients. Consequently, the features of HE identified cannot be compared rigorously with other forms of IE.

The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) was designed to provide a large multi-national resource of prospectively collected, well defined patients of IE using a standardised data set. The objective is to improve understanding of the clinical characteristics and outcome of IE in a multi-national cohort of patients. In this report we describe the characteristics of patients with HE, and compare the risk factors, clinical characteristics, and outcomes of HE with IE caused by other pathogens (non-HE).

Item ID: 52189
Item Type: Article (Research - C1)
ISSN: 1932-6203
Additional Information:

* International Collaboration on Endocarditis – Prospective Cohort Study

© 2013 Chambers et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funders: American Heart Association (AHA), International Society of Cardiovascular Infectious Disease, International Society of Chemotherapy, Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Spanish Network for Research in Infectious Diseases (REIPI), Fundacion Privada Maximo Soriano Jimenez
Projects and Grants: AMA 675027N, REIPI RD06/0008
Date Deposited: 30 Jan 2018 00:30
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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