Rothia dentocariosa endophthalmitis following intravitreal injection-a case report

Hayes, R.A., Bennett, H.Y., and O'Hagan, S. (2017) Rothia dentocariosa endophthalmitis following intravitreal injection-a case report. Journal of Ophthalmic Inflammation and Infection, 7. 24.

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Purpose: This report describes the first recognised case of Rothia dentocariosa endophthalmitis following intravitreal injection.

Case report: A 57-year-old indigenous Australian diabetic female developed pain, redness and decreased vision 3 days after intravitreal aflibercept injection to the right eye-administered for diabetic vitreous haemorrhage with suspected macular oedema and proliferative diabetic retinopathy. Examination revealed best corrected visual acuity (BCVA) of hand movements, ocular hypertension and marked anterior chamber inflammation. The left eye was unaffected but had a BCVA of 6/24 due to pre-existing diabetic retinopathy. Vitreous culture isolated Rothia dentocariosa as the organism responsible for the endophthalmitis. The following treatment with intraocular cephazolin, vancomycin and ceftazidime, topical ciprofloxacin and gentamicin and systemic ciprofloxacin, the patient underwent vitrectomy. Nine weeks after onset, the patient's BCVA had improved to 6/36, and fundal examination revealed extensive retinal necrosis.

Conclusion: Rothia dentocariosa is presented as a rare cause of endophthalmitis following intravitreal injection and reports the appearance of 'pink hypopyon' previously observed with other organisms. Its identification also demonstrates the risk of oral bacterial contamination during intraocular injections. Vigilance with strategies to minimise bacterial contamination in the peri-injection period are important. Further research to identify additional techniques to prevent contamination with oral bacteria would be beneficial, including whether a role exists for patients wearing surgical masks during intravitreal injections.

Item ID: 51955
Item Type: Article (Research - C1)
ISSN: 1869-5760
Keywords: anti-VEGF, aflibercept, endophthalmitis, intraocular, intravitreal injection, Rothia dentocariosa
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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Date Deposited: 10 Jan 2018 07:50
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3212 Ophthalmology and optometry > 321201 Ophthalmology @ 100%
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