Application note 56: photodecarboxylative addition of phenylacetic acid to N-methyl phthalimide

Josland, Sam, and Oelgemöller, Michael (2017) Application note 56: photodecarboxylative addition of phenylacetic acid to N-methyl phthalimide. Report. Vapourtec Ltd, Suffolk, UK.

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Abstract

This application note illustrates the use of the Vapourtec UV-150 photochemical reactor for the photodecarboxylative benzylation of N-methylphthalimide. The transformation has been systematically optimized in terms of reagent concentration and residence time. The optimized procedure was subsequently performed on large-scale, achieving a productivity of 1.34 g (88%) of product per hour (or 32.16 g per day). The reactor enabled continuous photochemistry in an easy-to-use, safe and efficient manner.

Item ID: 51806
Item Type: Report (Report)
Keywords: photochemistry; photodecarboxylation; photobenzylation; flow chemistry; organic chemistry; flow photochemistry
Funders: Australian Research Council (ARC)
Projects and Grants: ARC Discovery Project DP130100794
Date Deposited: 19 Dec 2017 04:03
FoR Codes: 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030503 Organic Chemical Synthesis @ 60%
03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030505 Physical Organic Chemistry @ 40%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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