Effects of omega-3 PUFA on immune markers in adolescent individuals at ultra-high risk for psychosis: results of the randomized controlled Vienna omega-3 study

Smesny, Stefan, Milleit, Berko, Schaefer, Miriam R., Hesse, Jana, Schlögelhofer, Monika, Langbein, Kerstin, Hipler, Uta-Christina, Berger, Maximus, Cotter, David R., Sauer, Heinrich, McGorry, Patrick D., and Amminger, G. Paul (2017) Effects of omega-3 PUFA on immune markers in adolescent individuals at ultra-high risk for psychosis: results of the randomized controlled Vienna omega-3 study. Schizophrenia Research, 188. pp. 110-117.

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Alterations of immune function have been reported in ultra-high risk (UHR) for psychosis patients causing expectations in terms of predictive meaningfulness and benefits of anti-inflammatory agents. According to a RCT in UHR-patients supplementation of omega-3 polyunsaturated fatty acids (PUFA) was effective in reducing transition to psychosis risk and to improve symptomatology. Based on preclinical findings, we now investigated state marker properties of and the influence of PUFA on immune markers in a RCT (clinical trials.gov Identifier: NCT00396643).

In a longitudinal design we measured plasma levels of the pro-inflammatory interleukin 6 (IL-6), the soluble alpha (Tac) subunit of the interleukin 2 receptor (sIL-2r), and the circulating soluble form of the intercellular adhesion molecule one (sICAM-1), in 79 help-seeking UHR individuals (13-25 years of age). Using linear mixed model (LMM) analysis, we investigated the effects of 12 weeks supplementation of either 1.2 g/d PUFA (n = 38) or Placebo (n = 41).

At baseline, inflammatory markers were not altered in patients who later suffered transition to psychosis within one year (n = 12; 11 PUFA-group, 1 PL-group). IL-6 was weakly inverse associated with omega-6 PUFA, and highly increased in nicotine users. In univariate tests of the LMM omega-3 PUFA caused a significant increase of sICAM-1 (p = 0.022). PUFA did not significantly influence IL-6 or sIL-2r.

The enhancement of sICAM-1 in the PUFA condition is suggestive for supportive effects on vascular immune response and immediate Th1 helper cell mediated immune answer, which was found disturbed in manifest schizophrenia, e.g. by facilitating the leukocyte adhesion and migration across the endothelium.

Item ID: 51724
Item Type: Article (Research - C1)
ISSN: 1573-2509
Keywords: at-risk mental state, cytokines, interleukins, inflammation, endothelium, biomarker, psychosis, immune function, indicated prevention
Funders: Stanley Medical Research Institute (SMRI), German Research Foundation (DFG), National Health and Medical Research Council (NHMRC), James Cook University (JCU)
Projects and Grants: SMRI Grant 03T-315, DFG Grant Sm68/3-1, NHMRC no. 566529, JCU Postgraduate Research Scholarship
Date Deposited: 06 Dec 2017 07:41
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320221 Psychiatry (incl. psychotherapy) @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
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