Ultrasound imaging of the renal parenchyma of premature neonates for the assessment of renal growth and glomerulomegaly

Brennan, Sonja, and Kandasamy, Yogavijayan (2017) Ultrasound imaging of the renal parenchyma of premature neonates for the assessment of renal growth and glomerulomegaly. Ultrasound in Medicine and Biology, 43 (11). pp. 2546-2549.

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Abstract

Evidence is increasingly showing that prematurity results in chronic kidney disease. We hypothesized that we could use ultrasound imaging to measure and monitor the growth of the renal parenchyma in premature neonates. We conducted a prospective, case-control study to compare renal parenchymal growth between neonates born prematurely and term neonates. The study patients underwent ultrasound assessment at 32 wk postmenstrual age (PMA) and 37 wk PMA. Term neonates (gestation > 37 completed wk) admitted to the neonatal unit with minor neonatal conditions were recruited into the control group. Complete data sets were available in 91 premature neonates and during the same period, 56 term neonates were recruited as the control. The median birth weight (preterm babies) was 930 g (780-1220 g), and the mean gestational age was 27.0 wk (2.1 wk). Total renal volume (TRV) increased from 14.6 (4.3) cm(3) to 20.5 (5.3) cm(3) from 32 to 37 wk PMA. During the same period, the total renal parenchyma (TRP) thickness increased from 1.6 (0.3) cm to 1.8 (0.3) cm. At 37 wk PMA, expremature neonates have a significantly smaller total renal volume (20.5 [5.3] versus 25.9 [6.4] cm(3); p < 0.001) and total renal parenchyma thickness (1.8 [0.3] versus 2.0 [0.2] cm; p = 0.015) compared with term (control) neonates. However, premature neonates at 37 wk PMA have a larger TRP: TRV ratio compared with term neonates (0.09 [0.02] versus 0.0 8 [0.02] cm(-2); p < 0.001). Reduced nephron endowment as a result of prematurity may cause the remaining nephrons to undergo compensatory glomerulomegaly and we postulate this is the reason for the observed differences. Ultrasound imaging of the renal parenchyma shows promise in assessing the effects of prematurity on the developing kidney.

Item ID: 51717
Item Type: Article (Research - C1)
ISSN: 1879-291X
Keywords: renal parenchyma, premature, preterm, renal, glomerulomegaly
Funders: National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: NHMRC APP1066971
Date Deposited: 06 Dec 2017 07:34
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110320 Radiology and Organ Imaging @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1114 Paediatrics and Reproductive Medicine > 111401 Foetal Development and Medicine @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920114 Reproductive System and Disorders @ 100%
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