Association Between Cytokines and Cerebral MRI Changes in the Aging Brain

Baune, Bernhard T., Ponath, Gerald, Rothermundt, Matthias, Roesler, Andreas, and Berger, Klaus (2009) Association Between Cytokines and Cerebral MRI Changes in the Aging Brain. Journal of Geriatric Psychiatry and Neurology, 22 (1). pp. 23-34.

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Abstract

The association between cytokines (IL-1β, sIL-4R, IL-6, IL-8, IL-10, IL-12, TNF-α) and subcortical white matter lesions, cortical atrophy and lacunar infarctions of the aging brain was investigated among 268 elderly community participants. Single pro- and anti-inflammatory cytokines were neither associated with WML nor with atrophy and lacunar infarction. An association between atrophy and the chemokine-cytokine factor (containing sIL-4R, IL-6, IL-8) remained significant after adjustment for age, gender, education, depressive symptoms, diabetes mellitus, cardiovascular diseases (stroke, TIA, myocardial infarction, myocardial insufficiency, arrhythmic heart), hypertension, body-mass index, smoking status and aggregation inhibitors as opposed to single cytokines. Atrophy of the parietal, temporal and occipital lobes was associated with the same cytokinechemokine factor for both the whole sample or restricted to those without history of stroke/TIA. The results indicate that a combination of chemokine-cytokines rather than single cytokines may contribute to inflammatory processes associated with cortical atrophy in the aging brain.

Item ID: 5127
Item Type: Article (Refereed Research - C1)
Keywords: white matter lesions, atrophy, lacunar infarctions, aging, cytokines
ISSN: 1552-5708
Date Deposited: 26 Aug 2009 04:28
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920502 Health Related to Ageing @ 100%
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