Aptamer-based therapeutic approaches to target cancer wtem cells

Zhou, Gang, Latchoumanin, Olivier, Bagdesar, Mary, Hebbard, Lionel, Duan, Wei, Liddle, Christopher, George, Jacob, and Qiao, Liang (2017) Aptamer-based therapeutic approaches to target cancer wtem cells. Theranostics, 7 (16). pp. 3948-3961.

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Abstract

Cancer stem cells (CSCs) are believed to be a principal cellular source for tumour progression and therapeutic drug resistance as they are capable of self-renewal and can differentiate into cancer cells. Importantly, CSCs acquire the ability to evade the killing effects of cytotoxic agents through changes at the genetic, epigenetic and micro-environment levels. Therefore, therapeutic strategies targeting CSCs hold great potential as an avenue for cancer treatment. Aptamers or "chemical antibodies" are a group of single-stranded nucleic acid (DNA or RNA) oligonucleotides with distinctive properties such as smaller size, lower toxicity and less immunogenicity compared to conventional antibodies. They have been frequently used to deliver therapeutic payloads to cancer cells and have achieved encouraging anti-tumour effects. This review discusses progress in CSC evolution theory and the role of aptamers to target CSCs for cancer treatment. Challenges of aptamer-mediated CSC targeting approaches are also discussed.

Item ID: 51259
Item Type: Article (Research - C1)
ISSN: 1838-7640
Keywords: aptamers, CSCs, cancer, drug resistance, antibodies, nanoparticles
Additional Information:

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

Funders: University of Sydney (US), Cancer Council of New South Wales (CC)
Projects and Grants: US Robert W. Storr Bequest, CC grant APP1070076
Date Deposited: 18 Oct 2017 07:37
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111209 Solid Tumours @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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