The realtionship between common patterns of prenatal alcohol exposure and the neurodevelopment of two-year old children

Halliday, Jane, Muggli, Evi, Elliott, Elizabeth, O'Leary, Colleen, Donath, Susan, Forster, Della, Lewis, Sharon, Nagle, Cate, Craig, Jeffrey, and Anderson, Peter (2017) The realtionship between common patterns of prenatal alcohol exposure and the neurodevelopment of two-year old children. Journal of Paediatrics and Child Health, 53 (S2). pp. 70-71.

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Background: Around 60% of women drink some alcohol while pregnant. There is conflicting evidence on the effect on the fetus of common patterns of prenatal alcohol exposure (PAE) e.g. low level or sporadic drinking. Guidelines recommend abstinence as the safest option, creating problems for those advising women who drink at these levels before pregnancy recognition or beyond. The Asking QUestions about Alcohol (AQUA) study aimed to accurately measure PAE and account for important cofactors, to reduce uncertainty about child outcomes.

Method: Detailed data on PAE were prospectively collected in a pre-birth cohort of over 1500 mother/child dyads. There was also extensive data collection of predictors of child development at one and two-year's post-partum. A sub-group of children was followed up at two years of age with a neurodevelopmental assessment (Bayley III). Two-step multivariable regression analyses of an effect of PAE accounted for independent risk factors that related to 1) pregnancy, including sociodemographic, psychologic and lifestyle variables such as diet and supplement use, and 2) the postnatal care-giving environment, including breastfeeding and maternal psychological wellbeing.

Results: Adjustment for independent risk factors ameliorated any putative associations between PAE and cognitive, language and motor development in 554 two year-old children spread evenly across six PAE groups.

Conclusions: Assessing neurodevelopmental outcomes associated with PAE is strongly influenced by other modifiable and non-modifiable risk factors. Although we found no adverse neurodevelopmental outcomes at two years of age, follow-up will be necessary in these children when complex higher-level cognitive, language and motor skills are required.

Item ID: 51247
Item Type: Article (Abstract)
ISSN: 1440-1754
Additional Information:

Presented at the 21st Annual Congress of the Perinatal Society of Australia and New Zealand (PSANZ), Canberra, Australia, 2-5 April 2017.

Date Deposited: 20 Oct 2017 04:54
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1114 Paediatrics and Reproductive Medicine > 111401 Foetal Development and Medicine @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1110 Nursing > 111006 Midwifery @ 50%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920507 Womens Health @ 50%
92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920501 Child Health @ 50%
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