Survival according to BRAF-V600 tumor mutations - An analysis of 437 patients with primary melanoma

Meckbach, Diana, Bauer, Jürgen, Pflugfelder, Annette, Meier, Friedegund, Busch, Christian, Eigentler, Thomas K., Capper, David, Mittelbronn, Michel, Von Deimling, Andreas, Perner, Sven, Ikenberg, Kristian, Hantschke, Markus, Büttner, Petra, Garbe, Claus, and Weide, Benjamin (2014) Survival according to BRAF-V600 tumor mutations - An analysis of 437 patients with primary melanoma. PLoS ONE, 9 (1). e86194. pp. 1-10.

[img]
Preview
PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (469kB) | Preview
View at Publisher Website: http://dx.doi.org/10.1371/journal.pone.0...
 
28
21


Abstract

The prognostic impact of BRAF-V600 tumor mutations in stage I/II melanoma patients has not yet been analyzed in detail. We investigated primary tumors of 437 patients diagnosed between 1989 and 2006 by Sanger sequencing. Mutations were detected in 38.7% of patients and were associated with age, histological subtype as well as mitotic rate. The mutational rate was 36.7% in patients with disease-free course and 51.7% in those with subsequent distant metastasis (p = 0.031). No difference in overall survival (p = 0.119) but a trend for worse distant-metastasis-free survival (p = 0.061) was observed in BRAF mutant compared to BRAF wild-type patients. Independent prognostic factors for overall survival were tumor thickness, mitotic rate and ulceration. An interesting significant prognostic impact was observed in patients with tumor thickness of 1 mm or less, with the mutation present in 6 of 7 patients dying from melanoma. In conclusion, no significant survival differences were found according to BRAF-V600 tumor mutations in patients with primary melanoma but an increasing impact of the mutational status was observed in the subgroup of patients with tumor thickness of 1 mm or less. A potential role of the mutational status as a prognostic factor especially in this subgroup needs to be investigated in larger studies.

Item ID: 51017
Item Type: Article (Research - C1)
ISSN: 1932-6203
Additional Information:

© 2014 Meckbach et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Date Deposited: 04 Oct 2017 02:48
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111202 Cancer Diagnosis @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
Downloads: Total: 21
Last 12 Months: 15
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page