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Abstract

[Extract] Dendritic cells (DCs) are sparsely but widely distributed cells of hematopoietic origin that are specialized for the capture, processing and presentation of antigens to T cells. They also play an important role in innate immune function. DCs are heterogeneous and differ in location, migratory pathways and immuno-logic function. While DCs are the major cells of the immune system that promote immune response to foreign antigens, it has become increasingly clear that these antigen-presenting cells (APCs) are also involved in promoting tolerance to self-antigens. This is because DCs that carry foreign antigens from the periphery into the lymph nodes must also carry self-antigens. Based on their role in both immunity and tolerance, and their capacity to educate the various players, or effectors, in the immune response, these critical decision making cells have been called “masterminds” of the immune system.1

Item ID:	50877
Item Type:	Book Chapter (Scholarly Work)
ISBN:	978-0-323-05475-1
Keywords:	arthritis
Date Deposited:	13 Nov 2017 05:04
FoR Codes:	06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060111 Signal Transduction @ 33% 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 33% 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 34%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 33% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis) @ 34% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 33%
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