Effects of acute exercise on endothelial function in abdominal aortic aneurysm patients

Bailey, Tom G., Perissiou, Maria, Windsor, Mark, Schulze, Karl, Nam, Michael, Magee, Rebecca, Leicht, Anthony S., Green, Daniel J., Greaves, Kim, Golledge, Jonathan, and Askew, Christopher D. (2018) Effects of acute exercise on endothelial function in abdominal aortic aneurysm patients. American Journal of Physiology-Heart and Circulatory Physiology, 314 (1). H19-H30.

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Endothelial dysfunction is observed in patients with abdominal aortic aneurysm (AAA), who have increased risk of cardiovascular events and mortality. This study aimed to assess the acute effects of moderate and higher-intensity exercise on endothelial function, as assessed by flow mediated-dilation (FMD), in AAA patients (n=22; 74±6 y) and healthy adults (n=22; 72±5y). Participants undertook three randomised visits, including moderate-intensity continuous exercise (40% peak power output, PPO), higher-intensity interval exercise (70% PPO), and a no-exercise control. Brachial artery FMD was assessed at baseline, 10- and 60-min after each condition. Baseline FMD was lower in AAA patients compared to healthy adults [by 1.10%, (95% CI, 0.72 to 1.81), P=0.044]. There were no group differences in the FMD responses after each condition(P=0.397). FMD did not change after the control condition, but increased by 1.21% (95% CI, 0.69 to 1.73, P<0.001) 10 min after moderate-intensity continuous exercise in both groups, and returned to baseline levels after 60-min. Conversely, FMD decreased by 0.93% (95% CI, 0.41 to 1.44, P<0.001) 10-min after higher-intensity interval exercise in both groups, and remained decreased after 60 min. This study found that the acute response of endothelial function to exercise is intensity-dependent and similar between AAA patients and healthy adults. This provides evidence that regular exercise may improve vascular function in AAA, as it does in healthy adults. Improved FMD following moderate-intensity exercise may provide short-term benefit. Whether the decrease in FMD following higher-intensity exercise represents additional risk and/or a greater stimulus for vascular adaptation remains to be elucidated.

Item ID: 50800
Item Type: Article (Research - C1)
ISSN: 1522-1539
Keywords: abdominal aortic aneurysm; exercise; endothelial function; flow-mediated dilation; cardiovascular risk
Funders: National Health and Medical Research Council (NHMRC), Townsville Hospital, University of the Sunshine Coast, Queensland Government (QG)
Projects and Grants: NHMRC grant 1000967, NHMRC grant 1022752, NHMRC grant 1079369, NHMRC Principal Research Fellowship 1090914, NHMRC fellowship 1117061, QG Senior Clinical Research Fellowship
Date Deposited: 27 Sep 2017 03:11
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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