Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations

Li, Yaqi, Yin, Mingbo, Wu, Qunfeng, McManus, Donald P., Blair, David, Li, Hongyan, Xu, Bin, Mo, Xiaojin, Feng, Zheng, and Hu, Wei (2017) Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations. Parasites & Vectors, 10 (87).

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Abstract

Background: The blood fluke, Schistosoma japonicum still causes severe disease in China, the Philippines and Indonesia. Although there have been some studies the molecular epidemiology of this persistent and harmful parasite, few have explored the possibility and implications of selection in S. japonicum populations.

Methods: We analyzed diversity and looked for evidence of selection at three nuclear genes (SjIpp2, SjFabp and SjT22.6) in 13 S. japonicum populations.

Results: SjT22.6 was found to exhibit high nucleotide diversity and was under positive selection in the mountainous region of mainland China. As a tegumental protein, its secondary and tertiary structure differed between S. japonicum strains from the mountainous and lakes regions. In contrast, SjIpp2 and SjFabp had relatively low levels of nucleotide diversity and did not show significant departure from neutrality.

Conclusions: As a tegument-associated antigen-encoding gene of S. japonicum, SjT22.6 has high nucleotide diversity and appears to be under positive selection in the mountainous region of mainland China.

Item ID: 50762
Item Type: Article (Refereed Research - C1)
Keywords: schistosoma japonicum, nuclear genes, genetic diversity, natural selection, tegument-associated antigen
Additional Information:

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

ISSN: 1756-3305
Funders: National Natural Science Foundation of China (NNSFC), Foundation of National Science and Technology (FNST)
Projects and Grants: NNSFC No. 91431104, FNST Grant No. 2012ZX10004-220, FNST Grant No. 2008ZX10004-011
Date Deposited: 20 Sep 2017 11:41
FoR Codes: 06 BIOLOGICAL SCIENCES > 0608 Zoology > 060802 Animal Cell and Molecular Biology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 100%
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