Role of killer-associated protein NKG7 in NK and NKT cells

Baxter, A.G., Gemiarto, A., Oliaro, J., Dinh, T.X., Smith, L., Godfrey, D.I., and Jordan, M.A. (2016) Role of killer-associated protein NKG7 in NK and NKT cells. European Journal of Immunology, 46 (S1). p. 181.

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Abstract

NKG7 is a poorly characterised integral membrane protein expressed on cytotoxic granules of quiescent NK and CD8 T cells and is translocated to the plasma membrane of cytotoxic cells following target engagement. It is expressed on expanded populations of cytotoxic CD4 T cells in patients with effective antiviral responses to HIV and CMV. In a transcriptional analysis of NKT cell development, we found that Nkg7is one of the most strongly up-regulated transcripts (35-fold) in NKT cells at the point of lineage commitment, suggesting it plays an important role in NKT cell activities. We have produced B6.Nkg7-/-mice and found a decrease in NK cell-mediated cytotoxicity on a per cell basis in vitro, but not an effect on numbers of peripheral NK cells. B6.Nkg7-/-mice had fewer thymic resident NK1.1+NKT cells but increased numbers in spleen and liver. The expression of the NK1.1 marker in NKT cells was associated with a “killer transcriptional program,” including strong expression of Nkg7, Gzma, Gzmb, Prf1, Fasland a wide range of NK cell markers that were not expressed on other subsets.

Item ID: 50541
Item Type: Article (Abstract)
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Presented at ICI 2016 International Congress of Immunology 21-26 August 2016, Melbourne, Australia

ISSN: 1521-4141
Date Deposited: 22 Sep 2017 03:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110706 Immunogenetics (incl Genetic Immunology) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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