Helminth infection-induced malignancy

Brindley, Paul J., and Loukas, Alex (2017) Helminth infection-induced malignancy. PLoS Pathogens, 13 (7). e1006393.

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Infectious diseases cause more than 20% of cancers in the developing world [1]. About a dozen pathogens including Epstein-Barr virus and human T cell lymphocytotropic virus 1 are among the well-known examples. In addition, infection with several trematodes, which are eukaryotes, can cause malignancy. The International Agency for Research on Cancer categorizes infection with the fish-borne trematodes Opisthorchis viverrini and Clonorchis sinensis and the blood fluke Schistosoma haematobium as Group 1 biological carcinogens [2]. In addition to parasitism directly damaging development, health, and prosperity of infected populations, infection with these helminths leads to cholangiocarcinoma (CCA) (bile duct cancer) and squamous cell carcinoma (SCC) of the urinary bladder, respectively [2]. By contrast, infection with phylogenetic relatives, also trematodes of the phylum Platyhelminthes and also major pathogens, is not carcinogenic. These irregularities suggest that either helminth-specific metabolites contribute to tumorigenesis and/or that certain tissues or organs are particularly susceptible to infection-induced malignancy. Moreover, each of these helminth infections must be viewed holistically in the context of a perfect storm of risk for cancer (see [3]).

Item ID: 50444
Item Type: Article (Research - C1)
ISSN: 1553-7366
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© 2017 Brindley, Loukas. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funders: National Health and Medical Research Council of Australia (NHMRC), National Institute of Allergy and Infectious Disease (NIAID), Tropical Medicine Research Centre (TMRC), National Cancer Institute (NCI)
Projects and Grants: TMRC award P5AI098639, NCI award R01CA1647
Date Deposited: 20 Sep 2017 09:04
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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