Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?

Saiz, Juan-Carlos, Martin-Acebes, Miguel A., Bueno-Mari, Ruben, Salomon, Oscar D., Villamil-Jimenez, Luis C., Heukelbach, Jorg, Alencar, Carlos H., Armstrong, Paul K., Ortiga-Carvalho, Tania M., Mendez-Otero, Rosalia, Rosado-de-Castro, Paulo H., and Pimentel-Coelho, Pedro M. (2017) Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic? Frontiers in Microbiology, 8. 1554.

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Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy. A large number of studies have been published in the last 3 years, revealing the structure of the virus, how it is transmitted and how it affects human cells. Many different animal models have been developed, which recapitulate several features of ZIKV disease and its neurological consequences. Moreover, several vaccine candidates are now in active preclinical development, and three of them have already entered phase I clinical trials. Likewise, many different compounds targeting viral and cellular components are being tested in in vitro and in experimental animal models. This review aims to discuss the current state of this rapidly growing literature from a multidisciplinary perspective, as well as to present an overview of the public health response to Zika and of the perspectives for the prevention and treatment of this disease.

Item ID: 50369
Item Type: Article (Research - C1)
ISSN: 1664-302X
Keywords: flavivirus, epidemiology, microcephaly, Guillain-Barre syndrome, antivirals
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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Funders: Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), INIA, Ministerio de Economia, Industria y Competitividad (MINECO)
Projects and Grants: FAPERJ e-26/201.341/2016, INIA ZIKA-BIO-2016-2, INIA RTA2013-0013-C04-01-E, INIA RTA2015-00009, MINECO AGL2014-56518-JIN
Date Deposited: 20 Sep 2017 08:20
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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