Longevity Klotho gene polymorphism and the risk of dementia in older men

Almedida, Osvaldo P., Morar, Bharti, Hankey, Graeme J., Yeap, Bu B, Golledge, Jonathan, Jablensky, Assen, and Flicker, Leon (2017) Longevity Klotho gene polymorphism and the risk of dementia in older men. Maturitas, 101. pp. 1-5.

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Abstract

Introduction: Klotho variants (KL-VS) have been associated with increased longevity and better cognitive function. It is unclear whether they modulate dementia risk.

Methods: We recruited 527 men aged 71-87 years who were free of cognitive impairment. We used data linkage to track the onset of dementia over 10 years. KL-VS genotyping (rs9536314 T/G) followed standard procedures.

Results: The annual rate of dementia was 17.2%o (95%CI = 14.0-21.1; total = 5053 person-years), and 14.0%o (95%CI = 10.6-18.4; 3582 person-years), 23.5%o (95%CI = 16.6-33.2; 1363 person-years) and 46.4%o (95%CI = 19.3-111.5; 108 person-years) for men with the TT, TG and GG genotypes. Compared with the TT genotype, the sub-hazard ratios of dementia associated with the TG and GG genotypes were 1.6 (95%CI = 1.0, 2.5; p = 0.030) and 3.5 (95%CI = 1.3, 9.1; p = 0.011).

Discussion: The Klotho KL-VS variant is associated with an increase in the incidence of dementia in older men, in a dose-dependent fashion (intermediate for heterozygosis and highest for homozygosis).

Item ID: 50322
Item Type: Article (Research - C1)
ISSN: 0378-5122
Keywords: klotho, epidemiology, cohort study, risk factor, dementia, alzheimer, cognitive impairment
Date Deposited: 20 Sep 2017 07:53
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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