Challenges and opportunities in limiting abdominal aortic aneurysm growth

Golledge, Jonathan, Norman, Paul E., Murphy, Michael P., and Dalman, Ronald L. (2017) Challenges and opportunities in limiting abdominal aortic aneurysm growth. Journal of Vascular Surgery, 65 (1). pp. 225-233.

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Objective: This review describes ongoing efforts to develop a medical therapy to limit abdominal aortic aneurysm (AAA) growth.

Methods: Data from animal model studies, human investigations, and clinical trials are described.

Results: Studies in rodent models and human samples have suggested a number of potential targets for slowing or halting AAA growth. A number of clinical trials are now examining the value of medications targeting some of the pathways identified. These trials have a number of challenges, including identifying medications safe to use in older patients with multiple comorbidities, developing accurate outcome assessments, and minimizing the dropout of patients during the trials. Three recent trials have reported no benefit of the antibiotic doxycycline, a mast cell inhibitor, an angiotensin-converting enzyme inhibitor, or a calcium channel blocker in limiting AAA growth. A number of other trials examining angiotensin receptor blockers, cyclosporine, and an antiplatelet agent are currently underway.

Conclusions: Further refinement of drug discovery pathways and testing paradigms are likely needed to develop effective nonsurgical therapies for AAA.

Item ID: 50321
Item Type: Article (Research - C1)
ISSN: 1097-6809
Date Deposited: 20 Sep 2017 07:53
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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