Excessive alcohol consumption increases mortality in later life: a genetic analysis of the health in men cohort study

Almeida, Osvaldo P., Mccaul, Kieran, Hankey, Graeme J., Yeap, Bu B., Golledge, Jonathan, and Flicker, Leon (2017) Excessive alcohol consumption increases mortality in later life: a genetic analysis of the health in men cohort study. Addiction Biology, 22 (2). pp. 570-578.

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We designed this cohort study of men aged 70-89 years to determine if excessive alcohol use increases mortality. They reported history of alcohol use (never, past, <= two daily drinks, two to four daily drinks, four to six daily drinks, >six daily drinks) and donated a blood sample in 2001-2004. We determined the ADH1B rs1229984 G>A polymorphism and retrieved mortality data from the Western Australian Data Linkage System. Other study measures included age, education, body mass index, smoking, and history of hypertension, diabetes, chronic respiratory diseases, coronary heart disease and stroke. Of the 3496 participants, 225 (6.4 percent) carried the ADH1B rs1229984 G>A polymorphism. Carriers consumed significantly less alcohol than non-carriers. The adjusted mortality hazard ratio (MHR, 95 percent confidence interval-95% CI) over 8.0 years (range: 10weeks to 11.2 years) relative to never drinkers was 1.15 (95% CI = 0.86, 1.55) for past drinkers, 0.98 (95% CI = 0.76, 1.25) for men consuming = two daily drinks, 1.13 (95% CI = 0.85, 1.49) for two to four drinks, 1.18 (95% CI = 0.81, 1.71) for four to six drinks and 1.87 (95% CI = 1.11, 3.12) for those consuming more than six daily drinks on a regular basis. The MHR associated with the ADH1B rs1229984 G>A polymorphism was 0.68 (95% CI= 0.54, 0.87). Excessive alcohol use in later life is associated with increased mortality, and this association is likely to be causal. We found no evidence that light to moderate alcohol use decreases the mortality of older men. Health messages regarding the safe use of alcohol in older age may benefit from taking these findings into account.

Item ID: 50318
Item Type: Article (Research - C1)
ISSN: 1369-1600
Keywords: ageing, alcohol, alcohol dehydrogenase, Mendelian randomisation, mortality, rs1229984 polymorphism
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC 279408, NHMRC 379600, NHMRC 403963, NHMRC 513823, NHMRC 540403, NHMRC 540404, NHMRC 540405, NHMRC 634492, NHMRC 1021416, NHMRC 1045710, NHMRC 1060557
Date Deposited: 20 Sep 2017 07:53
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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