Li, Ming, and McDermott, Robyn (2017) Elevated fasting glucose and albuminuria may be a marker for all-cause mortality in Indigenous adults in North Queensland - a follow up study, 1998-2006. Journal of Diabetes and its Complications, 31 (4). pp. 708-714.

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Abstract

Aims: To document risk factors of all-cause mortality in a cohort of indigenous Australians from 23 communities of North Queensland during 1998-2006.

Methods: Among 2787 indigenous adults, baseline weight, waist circumference, blood pressure, fasting glucose, lipids, gamma-glutamyl transferase, urine albumin creatinine ratio, smoking, alcohol intake and physical activity were measured in 1998-2000. Deaths were ascertained from State Registry of Deaths, hospitalization and clinical records till 2006. Mortality risk factors were assessed using a Cox proportional-hazards model.

Results: The standardized all-cause mortality rate was 23.2/1000 person-years (95% CI 203-263/1000 pys). After adjusting for age, sex, and ethnicity, baseline plasm fasting glucose > = 5.5 mmol/L was associated with a 50% increased risk of death (HR 1.5, 95% Cl 1.2-2.0). Albuminuria was associated with all-cause mortality with a hazards ratio of 1.4 for microalbuminuria (95% CI 1.0-1.9) and 2.6 (95% CI 1.8-3.7) for macroalbuminuria. Gamma-glutamyl transferase > = 50 IU was associated with an increased risk of all-cause mortality by 40% (95% CI 1.04-1.8).

Conclusions: Fasting glycaemia, albuminuria, and gamma-glutamyl transferase, may be a marker for all-cause mortality within this cohort.

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