Pai, Saparna, and Khanna, Rajiv (2001) Role of LMP1 in immune control of EBV infection. Seminars in Cancer Biology, 11 (6). pp. 455-460.

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Abstract

The Epstein-Barr virus (EBV) encoded latent membrane protein (LMP1) plays a crucial role in the long-term persistence of this virus within the cells of the immune system. Not only is this protein critical for the transformation of resting B cells by EBV, it also displays pleiotropic effects on various cellular proteins expressed in the host cell. These include up-regulation of expression of B cell activation antigens, adhesion molecules and various components of the antigen processing pathway. Here we discuss how LMP1 acts like an expression 'switch' which, depending on the stage of EBV infection, manoeuvres various pathways that either modulate the immune system towards or against its survival.

Item ID:	50256
Item Type:	Article (Research - C1)
ISSN:	1096-3650
Keywords:	antigen processing, cytotoxic T cells, epitope, malignancy, HLA class I, transformation, nuclear antigens
Date Deposited:	19 Sep 2017 02:47
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110709 Tumour Immunology @ 34% 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 33% 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 33%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 34% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 33% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 33%
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