Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarction in patients with mixed peripheral artery disease presentations

Moxon, Joseph V., Jones, Rhondda E., Wong, Gerard, Weir, Jacquelyn M., Mellett, Natalie A., Kingwell, Bronwyn A., Meikle, Peter J., and Golledge, Jonathan (2017) Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarction in patients with mixed peripheral artery disease presentations. Atherosclerosis, 263. pp. 301-308.

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Abstract

Background and Aims: Despite current best care, patients with peripheral artery disease (PAD) remain at high risk of myocardial infarction and biomarkers to more accurately assess cardiovascular risk are needed. This study assessed the relationship between the serum lipidome and incident myocardial infarction in a cohort of PAD patients.

Methods: 265 PAD patients were followed up for a median of 23 months, during which 18 people suffered a myocardial infarction. Fasting serum concentrations of 332 lipid species were measured via mass spectrometry and their association with incident myocardial infarction was assessed via Cox regression. Secondary analyses investigated prognostic potential of specific lipid species.

Results: Total serum concentrations of alkyl-phosphatidylcholine and alkenylphospatidylcholine (plasmalogen) lipids were inversely associated with incident myocardial infarction after adjusting for multiple testing (hazards ratio (95% confidence intervals): 0.43 (0.24-0.74); p=0.032; and 0.28 (0.14-0.56), p=0.010, respectively). Specifically, 10 alkenylphosphatidylcholine species and 6 alkyl-phosphatidylcholine species were negatively associated with incident myocardial infarction after adjusting for traditional risk factors and correcting for multiple testing (hazards ratios ranging from 0.07-0.51, p<0.05). Incorporation of serum phosphatidylcholine plasmalogen species PC(P-40:6) concentration within analyses designed to determine subsequent myocardial infarction incidence led to an improvement in predictive accuracy compared to using traditional risk factors alone.

Conclusions: Serum concentrations of phosphatidylcholine plasmalogens and alkyl-phosphatidylcholines were negatively associated with incident myocardial infarction and have potential to act as novel prognostic markers in at-risk populations.

Item ID: 49544
Item Type: Article (Research - C1)
ISSN: 1879-1484
Keywords: myocardial infarction, plasmalogen, biomarker, peripheral artery disease
Funders: Queensland Government, James Cook University, National Health and Medical Research Council (NHMRC), Victorian State Government
Projects and Grants: NHMRC 1020955, 1022752, 1000967, 1029754, 1117061, 1042095 & 1059454
Date Deposited: 12 Jul 2017 01:11
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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