Walking training at the heart rate of pain threshold improves cardiovascular function and autonomic regulation in intermittent claudication: a randomized controlled trial

Chehuen, Marcel, Cucato, Gabriel G., Carvalho, Celso Ricardo F., Ritti-Dias, Raphael M., Wolosker, Nelson, Leicht, Anthony S., and Forjaz, Cláudia Lúcia M. (2017) Walking training at the heart rate of pain threshold improves cardiovascular function and autonomic regulation in intermittent claudication: a randomized controlled trial. Journal of Science and Medicine in Sport, 20 (10). pp. 886-892.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: http://dx.doi.org/10.1016/j.jsams.2017.0...
 
11
1


Abstract

Objectives: This study investigated the effects of walking training (WT) on cardiovascular function and autonomic regulation in patents with intermittent claudication (IC).

Design: Randomized controlled trial.

Methods: Forty-two male patients with IC (≥50 years) were randomly allocated into two groups: control(CG, n = 20, 30 min of stretching exercises) and WT (WTG, n = 22, 15 bouts of 2 min of walking interpolated by 2 min of upright rest—walking intensity was set at the heart rate of pain threshold). Both interventions were performed twice/week for 12 weeks. Walking capacity (maximal treadmill test),blood pressure (auscultatory), cardiac output (CO2rebreathing), heart rate (ECG), stroke volume, systemic vascular resistance, forearm and calf vascular resistance (plethysmography), and low (LF) and high frequency (HF) components of heart rate variability and spontaneous baroreflex sensitivity were measured at baseline and after 12 weeks of the study.

Results: WT increased total walking distance (+302 ± 85 m, p = 0.001) and spontaneous baroreflex sensitivity (+2.13 ± 1.07 ms/mmHg, p = 0.02). Additionally, at rest, WT decreased systolic and mean blood pressures (−10 ± 3 and −5 ± 2 mmHg, p = 0.001 and p = 0.01, respectively), cardiac output(−0.37 ± 0.24 l/min, p = 0.03), heart rate (−4 ± 2 bpm, p = 0.001), forearm vascular resistance (−8.5 ± 2.8 U,p = 0.02) and LF/HF (−1.24 ± 0.99, p = 0.001). No change was observed in the CG.

Conclusions: In addition to increasing walking capacity, WT improved cardiovascular function and autonomic regulation in patients with IC.

Item ID: 49495
Item Type: Article (Research - C1)
ISSN: 1878-1861
Keywords: peripheral arterial disease; blood pressure; hemodynamic; autonomic modulation; walking training
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (PROEX)
Projects and Grants: FAPESP 2009/17371-6, FAPESP 2012/16700-9, CNPq 141737/2012-3, CNPq 503111/2010-4, CNPq 304003/2014-0, CNPq 305987/2010-0
Date Deposited: 04 Jul 2017 05:29
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1106 Human Movement and Sports Science > 110602 Exercise Physiology @ 60%
11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 40%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page