Cryptococcal infections over a 15 year period at a tertiary facility & impact of guideline management

Gassiep, I., Douglas, J., Emeto, T.I., Crawley, K., and Playford, E.G. (2017) Cryptococcal infections over a 15 year period at a tertiary facility & impact of guideline management. In: [Presented at the ASID Annual Scientific Meeting 2017]. From: ASID Annual Scientific Meeting 2017: Infectious Disease into the Future, 29 March - 1 April 2017, Blue Mountains, NSW, Australia.

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Introduction: The aim of this research paper is to determine the incidence, risk factors and clinical outcome of all patients diagnosed and treated for cryptococcosis at our institution. We also aim to compare treatment outcome following introduction of the 2010 Infectious Disease Society of America (IDSA) guidelines.

Methods: Retrospective analysis of all patients diagnosed and treated for cryptococcal infection occurring between January 2001 and December 2015.

Results: Of 102 patients diagnosed with cryptococcal infection, 97 were eligible for study inclusion. There appears to be an overall increased incidence of cryptococcosis in both transplant and non-transplant cohorts with a peak in 2015 of 6 transplant and 13 non-transplant cases. 38/52 (73%) of identified isolates were C. neoformans, and 14/52 (27%) were C. gattii. Notably, 14/14 (100%) of C. gattii isolates were associated with meningitis, as compared to only 38/64 (59%) C. neoformans associated with meningitis (p: 0.003). It appears that patients presenting with cough are less likely to have meningitis, 17/27 (63%), (p: 0.005). When stratifying for culture positive meningitis lumbar puncture opening pressure, the median in the culture positive cohort was 31.5cmH2 O compared with 15.5cmH2O (p:0.036). Multiple admissions were required prior to diagnosis in the majority of cases with only 18/72 (25%) diagnosed on 1st presentation. Post-guideline mortality has improved from 17.1% to 6.1% (p: 0.046).

Conclusion: Cryptococcal infection remains relatively uncommon, but there appears to be an increasing trend in incidence. Overall mortality is relatively low and has improved since introduction of the 2010 IDSA guidelines.

Item ID: 49411
Item Type: Conference Item (Poster)
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This work has also been published as: Gassiep, Ian, Douglas, Joel, Emeto, Theophilus I., Crawley, Katherine, and Playford, Elliot G. (2018) Cryptococcal infections over a 15 year period at a tertiary facility and impact of guideline management. Mycoses. (In Press) and can be accessed through ResearchOnline@JCU at the related URL.

Date Deposited: 11 Jul 2017 01:30
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 80%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 20%
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