Association of restless legs syndrome, pain, and mood disorders in Parkinson's disease

Rana, Abdul Qayyum, Qureshi, Abdul Rehman M., Rahman, Labiba, Jesudasan, Ajantha, Hafez, Kevin K., and Rana, Mohammad A. (2016) Association of restless legs syndrome, pain, and mood disorders in Parkinson's disease. International Journal of Neuroscience, 126 (2). pp. 116-120.

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Abstract

Purpose/Aims: The objectives of the study were to analyze the association between Parkinson's disease and restless legs syndrome, and to explore the relationship between mood disorder comorbidity (anxiety and depression), pain, and restless legs syndrome.

Methods: This study included 123 Parkinson's disease patients and 123 non-Parkinson's disease patients matched for age and gender, and evaluated for anxiety severity, depression severity, pain severity, pain interference, pain disability, and restless legs syndrome prevalence. This was performed using semi-structured interviews and a neurological examination through the restless legs syndrome diagnostic criteria and the following inventories; Hospital Anxiety and Depression Scale, Brief Pain Inventory, and Pain Disability Index.

Results: Parkinson's disease patients had significantly greater anxiety severity, depression severity, pain severity, pain interference, pain disability, and restless legs syndrome prevalence in comparison to controls. In addition, Parkinson's disease patients comorbid for anxiety and depression had significantly greater pain severity, pain interference, and pain disability, but not RLS prevalence, in comparison to Parkinson's disease only, Parkinson's disease anxiety, and Parkinson's disease depression patients.

Conclusions: Pain interference, pain severity, and pain disability is greater among Parkinson's disease patients with anxiety and depression, in comparison to Parkinson's disease patients without anxiety and depression. On the contrary, the prevalence of restless legs syndrome was not found to be relevant.

Item ID: 49340
Item Type: Article (Research - C1)
ISSN: 1563-5279
Keywords: restless legs syndrome, pain, mood disorders, comorbidity, parkinson's disease
Date Deposited: 12 Jun 2017 03:05
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110905 Peripheral Nervous System @ 70%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111714 Mental Health @ 30%
SEO Codes: 92 HEALTH > 9202 Health and Support Services > 920209 Mental Health Services @ 100%
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