Affective disorders, psychosis and dementia in a community sample of older men with and without Parkinson's disease

Almeida, Osvaldo P., Mccaul, Kieran, Hankey, Graeme J., Yeap, Bu B., Golledge, Jonathan, and Flicker, Leon (2016) Affective disorders, psychosis and dementia in a community sample of older men with and without Parkinson's disease. PLoS ONE, 11 (9). e0163781. pp. 1-13.

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Abstract

Background: Dementia and affective and psychotic symptoms are commonly associated with Parkinson's disease, but information about their prevalence and incidence in community representative samples remains sparse.

Methods: We recruited a community-representative sample 38173 older men aged 65-85 years in 1996 and used data linkage to ascertain the presence of PD, affective disorders, psychotic disorders and dementia. Diagnoses followed the International Classification of Disease coding system. Age was recorded in years. Follow up data were available until December 2011.

Results: The mean age of participants was 72.5 years and 333 men (0.9%) had PD at study entry. Affective and psychotic disorders and dementia were more frequent in men with than without PD (respective odds ratios: 6.3 [95%CI = 4.7, 8.4]; 14.2 [95%CI = 8.4, 24.0] and 18.2 [95%CI = 13.4, 24.6]). Incidence rate ratios of affective and psychotic disorders were higher among men with than without PD, although ratios decreased with increasing age. The ageadjusted hazard ratio (HR) of an affective episode associated with PD was 5.0 (95%CI = 4.2, 5.9). PD was associated with an age-adjusted HR of 8.6 (95%CI = 6.1, 12.0) for psychotic disorders and 6.1 (95%CI = 5.5, 6.8) for dementia. PD and dementia increased the HR of depressive and psychotic disorders.

Conclusions: PD increases the risk of affective and psychotic disorders, as well as dementia, among community dwelling older men. The risk of a recorded diagnosis of affective and psychotic disorders decreases with increasing age.

Item ID: 49311
Item Type: Article (Research - C1)
ISSN: 1932-6203
Additional Information:

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funders: National Health and Medical Research Council of Australia (NHMRC).
Projects and Grants: NHMRC competitive project grant number 279408, NHMRC competitive project grant number 379600, NHMRC competitive project grant number 403963, NHMRC competitive project grant number 513823, NHMRC competitive project grant number 540403, NHMRC competitive project grant number 540504, NHMRC competitive project grant number 540405, NHMRC competitive project grant number 634492, NHMRC competitive project grant number 1021416, NHMRC competitive project grant number 1045710, NHMRC competitive project grant number 1060557
Date Deposited: 11 Jun 2017 23:58
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111714 Mental Health @ 20%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110308 Geriatrics and Gerontology @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110904 Neurology and Neuromuscular Diseases @ 50%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920502 Health Related to Ageing @ 30%
92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920505 Mens Health @ 30%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 40%
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