Advances in canine distemper virus pathogenesis research: a wildlife perspective

Loots, Angelika K., Mitchell, Emily, Dalton, Desiré L., Kotzé, Antoinette, and Venter, Estelle H. (2017) Advances in canine distemper virus pathogenesis research: a wildlife perspective. Journal of General Virology, 98. pp. 311-321.

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Canine distemper virus (CDV) has emerged as a significant disease of wildlife, which is highly contagious and readily transmitted between susceptible hosts. Initially described as an infectious disease of domestic dogs, it is now recognized as a global multi-host pathogen, infecting and causing mass mortalities in a wide range of carnivore species. The last decade has seen the effect of numerous CDV outbreaks in various wildlife populations. Prevention of CDV requires a clear understanding of the potential hosts in danger of infection as well as the dynamic pathways CDV uses to gain entry to its host cells and its ability to initiate viral shedding and disease transmission. We review recent research conducted on CDV infections in wildlife, including the latest findings on the causes of host specificity and cellular receptors involved in distemper pathogenesis.

Item ID: 49282
Item Type: Article (Research - C1)
ISSN: 1465-2099
Keywords: canine distemper virus; morbillivirus; wildlife; infectious diseases; SLAM; nectin-4
Funders: National Zoological Gardens of South Africa (NZGSA), National Research Foundation (NRF)
Projects and Grants: NRF Professional Development Program
Date Deposited: 14 Jun 2017 05:43
FoR Codes: 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3009 Veterinary sciences > 300914 Veterinary virology @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 100%
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