Trends and spatial patterns of mortality related to neglected tropical diseases in Brazil

Martins-Melo, Francisco Rogerlândio, Ramos, Alberto Novaes Jr., Alencar, Carlos Henrique, and Heukelbach, Jorg (2016) Trends and spatial patterns of mortality related to neglected tropical diseases in Brazil. Parasite Epidemiology and Control, 1 (2). pp. 56-65.

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We analysed nationwide trends and spatial distribution of NTD-related mortality in Brazil. We included all death certificates in Brazil from 2000 to 2011, in which NTDs were recorded as any causes of death. A total of 100,814/12,491,280 (0.81%) death certificates were identified, which mentioned at least one NTD. Age-adjusted NTD-related mortality rates showed a significant decrease over time (annual percent change [APC]: − 2.1%; 95% CI: − 2.8 to − 1.3), with decreasing mortality rates in the Southeast, South, and Central-West regions, stability in the Northeast region, and increase in the North region. We identified spatial and spatiotemporal high-risk clusters for NTD-related mortality in all regions, with a major cluster covering a wide geographic range in central Brazil. Despite nationwide decrease of NTD-related mortality in the observation period, regional differences remain, with increasing mortality trends especially in the socioeconomically disadvantaged regions of the country. The existence of clearly defined high-risk areas for NTD-related deaths reinforces the need for integrated prevention and control measures in areas with highest disease burden.

Item ID: 49187
Item Type: Article (Research - C1)
ISSN: 2405-6731
Keywords: neglected tropical diseases, time trend analysis, spatial analysis, epidemiology, mortality, Brazil
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© 2016 The Authors. Published by Elsevier Ltd on behalf of World Federation of Parasitologists. This is an open access article under the CC BY-NC-ND license (

Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date Deposited: 07 Jun 2017 00:28
FoR Codes: 42 HEALTH SCIENCES > 4202 Epidemiology > 420205 Epidemiological modelling @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 100%
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