Connecting brain proteomics with behavioural neuroscience in translational animal models of neuropsychiatric disorders

Sarnyai, Zoltán, and Guest, Paul (2017) Connecting brain proteomics with behavioural neuroscience in translational animal models of neuropsychiatric disorders. In: Guest, Paul C., (ed.) Proteomic Methods in Neuropsychiatric Research. Advances in Experimental Medicine and Biology, 974 . Springer, pp. 97-115.

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Abstract

Modelling psychiatric disorders in animals has been hindered by several challenges related to our poor understanding of the disease causes. This chapter describes recent advances in translational research which may lead to animal models and relevant proteomic biomarkers that can be informative about disease mechanisms and potential new therapeutic targets. The review focuses on the behavioural and molecular correlates in models of schizophrenia and major depressive disorder, as guided by recently established Research Domain Criteria (RDoC). This approach is based on providing proteomic data for aetiologically driven, behaviourally well-characterised animal models to link discovered biomarker candidates with the human disease.

Item ID: 48963
Item Type: Book Chapter (Research - B1)
ISBN: 978-3-319-52478-8
Date Deposited: 23 Jun 2017 05:48
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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