The potential role of kallistatin in the development of Abdominal Aortic Aneurysm

Li, Jiaze, Krishna, Smriti Murali, and Golledge, Jonathan (2016) The potential role of kallistatin in the development of Abdominal Aortic Aneurysm. International Journal of Molecular Sciences, 17 (8). 1312. pp. 1-14.

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Abstract

Abdominal aortic aneurysm (AAA) is a vascular condition that causes permanent dilation of the abdominal aorta, which can lead to death due to aortic rupture. The only treatment for AAA is surgical repair, and there is no current drug treatment for AAA. Aortic inflammation, vascular smooth muscle cell apoptosis, angiogenesis, oxidative stress and vascular remodeling are implicated in AAA pathogenesis. Kallistatin is a serine proteinase inhibitor, which has been shown to have a variety of functions, potentially relevant in AAA pathogenesis. Kallistatin has been reported to have inhibitory effects on tumor necrosis factor alpha (TNF-α) signaling induced oxidative stress and apoptosis. Kallistatin also inhibits vascular endothelial growth factor (VEGF) and Wnt canonical signaling, which promote inflammation, angiogenesis, and vascular remodeling in various pre-clinical experimental models. This review explores the potential protective role of kallistatin in AAA pathogenesis.

Item ID: 48843
Item Type: Article (Research - C1)
ISSN: 1422-0067
Keywords: kallistatin; serine proteinase inhibitors; abdominal aortic aneurysm; vascular remodelling; oxidative stress
Additional Information:

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Funders: National Health and Medical Research Council of Australia (NHMRC), Queensland Government, Townsville Hospital Private Practice Research Fund, James Cook University (JCU)
Projects and Grants: NHMRC 1079369, NHMRC 1098717, NHMRC 1019921, JCU-QLD-547271
Date Deposited: 03 May 2017 03:06
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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