Effects of in utero and postnatal exposure to secondhand smoke on lung function by gender and asthma status: The Seven Northeastern Cities (SNEC) Study

Hu, Li-Wen, Yang, Mo, Chen, Shu, Shah, Kuntal, Hailegiorgis, Yismaw, Burgens, Richai, Vaughn, Michael, Huang, Jin, Xaverius, Pamela, Paul, Gunther, Morawska, Lidia, Lu, Tao, Lin, Shao, Zhong, Shou-Qiang, Kong, Min-Li, Xie, Yan-Qi, Hao, Yuan-Tao, Zeng, Xiao-Wen, Qian, Zhengmin, and Dong, Guang-Hui (2017) Effects of in utero and postnatal exposure to secondhand smoke on lung function by gender and asthma status: The Seven Northeastern Cities (SNEC) Study. Respiration, 93 (3). pp. 189-197.

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Abstract

Background: Little information exists on whether gender or asthma status modifies the effects of secondhand smoke (SHS) exposure on lung function.

Objective: To evaluate whether gender or asthma status modifies the association of SHS exposure with lung function.

Methods: A total of 6,740 children (average 11.6 years were recruited from 24 districts of 7 cities in northeast China in 2012. SHS exposure included exposure to environmental and maternal smoking in utero and during early childhood (postnatal). Two-step regressions were used to analyze the association between SHS and lung function.

Results: In utero and postnatal exposure to SHS was independently associated with decreased lung function in both genders. For example, when exposed to maternal smoking during pregnancy, the adjusted odds ratio (aOR) for decreased forced vital capacity (FVC) was 6.46 (95% confidence interval [CI]: 2058-16.17) among males, while only 2.16 (95% CI: 0.96-4.88) among females. More positive associations between SHS exposure and decreased lung function were detected among nonasthmatic compared with asthmatic children. Nonasthmatics had significantly larger deficits from in utero exposure to maternal smoking, which concerned decreased lung FVC function (aOR = 2.58, 95% CI: 1.28-5.21) and decreased lung forced expiratory volume in 1 s (FEV1) function (aOR = 2.32, 95% CI: 1.01-5.33). A similar pattern was also observed for associations between SHS exposure and continuous pulmonary function test measurements.

Conclusion: SHS exposure was associated with decreased lung function. Males and nonasthmatics seem to be more susceptible than their respective counterparts.

Item ID: 48325
Item Type: Article (Research - C1)
ISSN: 1423-0356
Keywords: lung function, secondhand smoke, gender, asthma, interaction effect
Funders: National Key Research and Development Program of China (NKRDP)), National Natural Science Foundation of China (NNSFC), China Environmental Protection Foundation (CEPF), Guangdong Province Natural Science Foundation (GPNSF)
Projects and Grants: NKRDP Grant No. 2016YFC0207000, NNSFC Grant No. 91543208, CEPF Grant No. 2008-123-1-5, GPNSF Grant No. 2014A050503027, GPNSF Grant No. 2016A030313342
Date Deposited: 07 Apr 2017 00:40
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1114 Paediatrics and Reproductive Medicine > 111401 Foetal Development and Medicine @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111705 Environmental and Occupational Health and Safety @ 70%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920405 Environmental Health @ 100%
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