Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study

Li, Meng, Zeng, Xiao-Wen, Qian, Zhengmin (Min), Vaughn, Michael G., Sauvé, Sébastien, Paul, Gunther, Lin, Shao, Lu, Long, Hu, Li-Wen, Yang, Bo-Yi, Zhou, Yang, Qin, Xiao-Di, Xu, Shu-Li, Bao, Wen-Wen, Zhang, Ya-Zhi, Yuan, Ping, Wang, Jia, Zhang, Chuan, Tian, Yan-Peng, Nian, Min, Xiao, Xiang, Fu, Chuanxi, and Dong, Guang-Hui (2017) Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study. Environment International, 102. pp. 1-8.

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Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers' and infants' characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3 g (95% CI:−195.9, −56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2 g (95% CI:−103.1, −11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branchedPFOSisomers(1m-PFOS and 3 + 4 + 5m-PFOS)and gestationalage was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.

Item ID: 48323
Item Type: Article (Research - C1)
ISSN: 1873-6750
Keywords: polyfluoroalkyl substances (PFASs), isomers, birth weight, gestational age
Funders: National Natural Science Foundation of China (NNSFC), Project for Key Medicine Discipline Construction of Guangzhou Municipality (PKMCGM), Fundamental Research Funds for the Central Universities (FRFCU), Natural Science Foundation of Guangdong Province (NSFGP)
Projects and Grants: NNSFC grant No. 81472936, NNSFC grant No. 81673127, NNSFC grant No. 81172630, PKMCGM grant No. 2017-2019-07, FRFCU grant No. 16ykzd02, NSFGP grant No. 2016A030313342
Date Deposited: 06 Apr 2017 06:51
FoR Codes: 42 HEALTH SCIENCES > 4206 Public health > 420601 Community child health @ 30%
35 COMMERCE, MANAGEMENT, TOURISM AND SERVICES > 3505 Human resources and industrial relations > 350505 Occupational and workplace health and safety @ 70%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920405 Environmental Health @ 100%
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