Positive associations of serum Perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan

Qin, Xiao-Di, Qian, Zhengmin, Vaughn, Michael G., Huang, Jin, Ward, Patrick, Zeng, Xiao-Wen, Zhou, Yang, Zhu, Yu, Yuan, Ping, Li, Meng, Bai, Zhipeng, Paul, Gunther, Hao, Yuan-Tao, Chen, Wen, Chen, Pau-Chung, Dong, Guang-Hui, and Lee, Yungling (2016) Positive associations of serum Perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. Environmental Pollution, 212. pp. 519-524.

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To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in > 94% of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (\ensuremathβ=0.1463, p<0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR=2.16, 95%CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR=2.76, 95%CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.

Item ID: 48184
Item Type: Article (Research - C1)
ISSN: 1873-6424
Keywords: perfluoroalkyl substances, uric acid, hyperuricemia, child
Funders: National Science Council of Taiwan (NSC), National Natural Science Foundation of China (NNSFC), Guangdong Province Natural Science Foundation (GPNSF)
Projects and Grants: NSC Grant No. 98-2314-B-002-138-MY3, NSC Grant No. 101-2621-M-002-005, NNSFC Grant No. 81172630, NNSFC Grant No. 81472936, GPNSF Grant No. 2014A030313021
Date Deposited: 25 May 2017 03:48
FoR Codes: 42 HEALTH SCIENCES > 4206 Public health > 420601 Community child health @ 30%
35 COMMERCE, MANAGEMENT, TOURISM AND SERVICES > 3505 Human resources and industrial relations > 350505 Occupational and workplace health and safety @ 70%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920405 Environmental Health @ 100%
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