Associations of serum perfluoroalkyl acid levels with T-helper cell-specific cytokines in children: by gender and asthma status

Zhu, Yu, Qin, Xiao-Di, Zeng, Xiao-Wen, Paul, Gunther, Morawask, Lidia, Su, Ming-Wei, Tsai, Ching-Hui, Wang, Si-Quan, Lee, Yungling Leo, and Dong, Guang-Hui (2016) Associations of serum perfluoroalkyl acid levels with T-helper cell-specific cytokines in children: by gender and asthma status. Science of the Total Environment, 559. pp. 166-173.

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Abstract

Perfluoroalkyl acids (PFAAs) are a group of common chemicals that ubiquitously exist in wildlife and humans. Experimental data suggest that they may alter T-lymphocyte functioning in situ by preferentially enhancing the development of T-helper 2 (TH2)- and inhibiting TH1-lymphocyte development and might increase allergic inflammation, but few human studies have been conducted. To evaluate the association between serum PFAAs concentrations and T-lymphocyte-related immunological markers of asthma in children, and further to assess whether gender modified this association, 231 asthmatic children and 225 non-asthmatic control children from Northern Taiwan were recruited into the Genetic and Biomarker study for Childhood Asthma. Serum concentrations of ten PFAAs and levels of TH1 interferon (IFN)-{\ensuremath{\gamma}}, interleukin (IL)-2 and TH2 (IL-4 and IL-5) cytokines were measured. The results showed that asthmatics had significantly higher serum PFAAs concentrations compared with the healthy controls. When stratified by gender, a greater number of significant associations between PFAAs and asthma outcomeswere found in males than in females. Among males, adjusted odds ratios for asthma among those with the highest versus lowest quartile of PFAAs exposure ranged from 2.59 (95\% CI: 1.14, 5.87) for the perfluorobutanesulfonate (PFBS) to 4.38 (95\% CI: 2.02, 9.50) for perfluorooctanesulfonate (PFOS); and serum PFAAs were associated positively with TH2 cytokines and inversely with TH1 cytokines among male asthmatics. Among females, no significant associations between PFAAs and TH2 cytokines could be detected. In conclusion, increased serum PFAAs levels may promote TH cell dysregulation and alter the availability of key TH1 and TH2 cytokines, ultimately contributing to the development of asthma that may differentially impact males to a greater degree than females. These results have potential relevance in asthma prevention.

Item ID: 48180
Item Type: Article (Research - C1)
ISSN: 1879-1026
Keywords: Perfluoroalkyl acids (PFAAs), T-helper 1 cytokines, asthma
Funders: National Science Council of Taiwan (NSC), Nationaln Natural Science Foundation of China (NNSFC), Guangdong Province Natural Science Foundation (GPNSF)
Projects and Grants: NSC Grant No. 98-2314-B-002-138-MY-3, NNSFC Grant No. 81472936, NNSFC Grant No. 81172630, GPNSF Grant No. 2014A030313021
Date Deposited: 05 Jun 2017 02:08
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110203 Respiratory Diseases @ 20%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 80%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920115 Respiratory System and Diseases (incl. Asthma) @ 60%
92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920501 Child Health @ 40%
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