Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: by sex status

Zhou, Yang, Hu, Li-Wen, Qian, Zhengmin, Chang, Jen-Jen, King, Chris, Paul, Gunther, Lin, Shao, Chen, Pau-Chung, Lee, Yungling, and Dong, Guang-Hui (2016) Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: by sex status. Environment International, 94. pp. 189-195.

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Polyfluoroalkyl substances (PFASs) are a group of common chemicals that ubiquitously exist in wildlife and humans. However, few studies have researched the effect of PFASs on reproductive hormones in adolescents. To provide information in this regard, we recruited 225 Taiwanese adolescents aged 13-15 years from 2009 to 2010 to investigate the relationship between serum PFASs (PFOS, PFOA, PFBS, PFDA, PFDoA, PFHxA, PFHxS, PFNA and PFTA) and reproductive hormone concentrations using a cross-sectional study design. Results showed PFOS and PFTA levels were highest among the PFASs, with a median concentrations of 29.9 (interquartile range: 13.0-43.8) ng/mL and 6.0 (0.6-25.9) ng/mL in males, and a median concentrations of 28.8 (14.8-42.6) ng/mL and 4.5 (0.3-18.4) ng/mL in females. After adjustment for confounding factors, nonsignificant associations between PFASs and reproductive hormone were found except for PFNA with ln(estradiol) (\ensuremathβ=0.2060, 95%CI: 0.0016, 0.4105). When stratified by sex, more significant associations were found in males than in females. Among males, PFASs were negatively associated with ln(testosterone) level for PFOS (\ensuremathβ=-0.0029, 95%CI: -0.0055, - 0.0003), PFDA (\ensuremathβ=-0.2565, 95%CI: -0.4135,-0.0994), PFHxA (\ensuremathβ=-0.3095, 95%CI: -0.5942,-0.0248), and PFNA (\ensuremathβ=-0.4233, 95%CI:-0.6998, -0.1467). Furthermore, male participant ln(estradiol) levels were positively associated with PFOA (\ensuremathβ=0.0921, 95%CI: 0.0186, 0.1656), and PFHxS (\ensuremathβ=0.0462, 95%CI: 0.0020, 0.0905). Among females, a significant relationship was found only for PFDoA with ln(testosterone)(\ensuremathβ=-0.0119, 95%CI: -0.0227, -0.0010). In conclusion, this study showed higher levels of PFASs coincide with lower testosterone and higher estradiol levels, and more significant associations of PFASs with reproductive hormone were found in males than in females.

Item ID: 48177
Item Type: Article (Research - C1)
ISSN: 1873-6750
Keywords: perfluoroalkyl substances, testosterone, estradiol, sex, adolescents
Funders: National Natural Science Foundation of China (NNSFC), Fundamental Research Funds for the Central Universities of China (FRFCUC), National Science Council of Taiwan (NSC)
Projects and Grants: NNSFC grant #81472936, NNSFC grant #81172630, FRFCUC grant #16ykzd02, NSC grant #98-2314-B-002-138-MY3, NSC grant #101-2621-M-002-005
Date Deposited: 27 Jul 2017 03:36
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111705 Environmental and Occupational Health and Safety @ 100%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920501 Child Health @ 100%
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