Testosterone-mediated endocrine function and TH1/TH2 cytokine balance after prenatal exposure to perfluorooctane sulfonate: by sex status
Zhong, Shou-Qiang, Chen, Zan-Xiong, Kong, Min-Li, Xie, Yan-Qi, Zhou, Yang, Qin, Xiao-Di, Paul, Gunther, Zeng, Xiao-Wen, and Dong, Guang-Hui (2016) Testosterone-mediated endocrine function and TH1/TH2 cytokine balance after prenatal exposure to perfluorooctane sulfonate: by sex status. International Journal of Molecular Sciences, 17 (9). 1509. pp. 1-22.
|
PDF (Published Version)
- Published Version
Available under License Creative Commons Attribution. Download (3MB) | Preview |
Abstract
Little information exists about the evaluation of potential developmental immunotoxicity induced by perfluorooctane sulfonate (PFOS), a synthetic persistent and increasingly ubiquitous environmental contaminant. To assess potential sex-specific impacts of PFOS on immunological health in the offspring, using male and female C57BL/6 mice, pups were evaluated for developmental immunotoxic effects after maternal oral exposure to PFOS (0.1, 1.0 and 5.0 mg PFOS/kg/day) during Gestational Days 1—17. Spontaneous TH1/TH2-type cytokines, serum levels of testosterone and estradiol were evaluated in F1 pups at four and eight weeks of age. The study showed that male pups were more sensitive to the effects of PFOS than female pups. At eight weeks of age, an imbalance in TH1/TH2-type cytokines with excess TH2 cytokines (IL-4) was found only in male pups. As for hormone levels, PFOS treatment in utero significantly decreased serum testosterone levels and increased estradiol levels only in male pups, and a significant interaction between sex and PFOS was observed for serum testosterone at both four weeks of age (pinteraction = 0.0049) and eight weeks of age (pinteraction = 0.0227) and for estradiol alternation at four weeks of age (pinteraction = 0.0351). In conclusion, testosterone-mediated endocrine function may be partially involved in the TH1/TH2 imbalance induced by PFOS, and these deficits are detectable among both young and adult mice and may affect males more than females.
Item ID: | 48176 |
---|---|
Item Type: | Article (Research - C1) |
ISSN: | 1422-0067 |
Keywords: | perfluorooctane sulfonate, gender difference, testosterone, TH1/TH2 cytokine imbalance, estradiol, testosterone |
Additional Information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). |
Funders: | National Natural Science Foundation of China (NNSFC), Guangdong Province Natural Science Foundation (GPNSF), Fundamental Research Funds for the Central Universities (FRFCU) |
Projects and Grants: | NNSFC grant #81172630, NNSFC grant #81472936, GPNSF grant #2016A030313342, GPNSF grant #2014A030313021, FRFCU grant #16ykzd02 |
Date Deposited: | 27 Jul 2017 01:31 |
FoR Codes: | 35 COMMERCE, MANAGEMENT, TOURISM AND SERVICES > 3505 Human resources and industrial relations > 350505 Occupational and workplace health and safety @ 100% |
SEO Codes: | 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920501 Child Health @ 100% |
Downloads: |
Total: 1062 Last 12 Months: 12 |
More Statistics |