Superior myocardial protection using "polarizing" adenosine, lidocaine, and Mg2+ cardioplegia in humans

Onorati, Francesco, Dobson, Geoffrey P., San Biagio, Livio, Abbasciano, Riccardo, Fanti, Diego, Covajes, Cecilia, Menon, Tiziano, Gottin, Leonardo, Biancari, Fausto, Mazzucco, Alessandro, and Faggian, Giuseppe (2016) Superior myocardial protection using "polarizing" adenosine, lidocaine, and Mg2+ cardioplegia in humans. Journal of the American College of Cardiology, 67 (14). pp. 1751-1753.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: http://dx.doi.org/10.1016/j.jacc.2015.12...
 
4
3


Abstract

[Extract] Myocardial protection with current methods of cardioplegia is still incomplete. Several studies have shown that hyperkalemic solution may lead to cell injury. Adenosine-lidocaine-magnesium (ALM) is a new normokalemic, "polarizing" method of cardioplegia that arrests the heart at its resting membrane potential. Pre-clinical studies have shown ALM to provide improved protection compared with hyperkalemic solutions. A recent clinical trial also observed improved outcomes with ALM-enriched hyperkalemic cardioplegia. We hypothesized that normokalemic, "full-polarizing" ALM microplegia from induction to reanimation provides improved myocardial protection compared with hyperkalemic arrest.

Item ID: 48134
Item Type: Article (Research - C1)
ISSN: 1558-3597
Funders: University of Verona
Date Deposited: 04 Apr 2017 01:58
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
Downloads: Total: 3
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page