Detection and characterisation of papillomavirus in skin lesions of giraffe and sable antelope in South Africa

van Dyk, E., Bosman, A-M., van Wilpe, E., Williams, J.H., Bengis, R.G., van Heerden, J., and Venter, E.H. (2011) Detection and characterisation of papillomavirus in skin lesions of giraffe and sable antelope in South Africa. Journal of the South African Veterinary Association, 82 (2). pp. 80-85.

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Abstract

Papillomavirus was detected electron microscopically in cutaneous fibropapillomas of a giraffe (Giraffa camelopardalis) and a sable antelope (Hippotragus niger). The virus particles measured 45 nm in diameter. Histopathologically, the lesions showed histopathological features similar to those of equine sarcoid as well as positive immunoperoxidase-staining of tissue sections for papillomavirus antigen. Polymerase chain reaction (PCR) detected bovine papillomavirus (BPV) DNA. Bovine papillomavirus-1 was characterised by real-time PCR in the sable and giraffe, and cloning and sequencing of the PCR product revealed a similarity to BPV-1. As in the 1st giraffe, the lesions from a 2nd giraffe revealed locally malignant pleomorphism, possibly indicating the lesional end-point of papilloma infection. Neither virus particles nor positively staining papillomavirus antigen could be demonstrated in the 2nd giraffe but papillomavirus DNA was detected by real-time PCR which corresponded with BPV-1 and BPV-2.

Item ID: 47820
Item Type: Article (Research - C1)
ISSN: 0038-2809
Keywords: cutaneous fibropapillomas, Giraffa camelopardalis, giraffe, Hippotragus niger, malignant pleomorphism, papillomavirus, sable antelope
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All articles published in this journal are licensed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license, unless otherwise stated.

Funders: South African Veterinary Foundation, University of Pretoria
Date Deposited: 15 Mar 2017 07:38
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070712 Veterinary Virology @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 100%
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