Use of nanoparticles as contrast agents for the functional and molecular imaging of abdominal aortic aneurysm

Emeto, Theophilus I., Alele, Faith O., Smith, Felicity, Smith, Amy M., Dougan, Tammy, and Golledge, Jonathan (2017) Use of nanoparticles as contrast agents for the functional and molecular imaging of abdominal aortic aneurysm. Frontiers in Cardiovascular Medicine, 4. pp. 1-27.

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Abstract

Abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta common in adults older than 65 years of age. AAA is usually imaged using ultrasound or computed tomography. Molecular imaging technologies employing nanoparticles have been proposed as novel ways to quantify pathological processes, such as inflammation, within AAAs as a means to identify the risk of rapid progression or rupture. This article reviews the current evidence supporting the role of nanoparticle-based imaging in the management of AAA. Currently, ultrasmall superparamagnetic nanoparticles enhanced magnetic resonance imaging appears to hold the greatest potential for imaging macrophage-mediated inflammation in human AAA.

Item ID: 47671
Item Type: Article (Refereed Research - C1)
Keywords: abdominal aortic aneurysm, nanoparticles, diagnosis, human studies, animal studies
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© 2017 Emeto, Alele, Smith, Smith, Dougan and Golledge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ISSN: 2297-055X
Funders: National Health and Medical Research Council (NHMRC), Queensland Government, The Townsville Hospital and Health Service Research and Education Trust Fund
Date Deposited: 13 Mar 2017 22:51
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 70%
10 TECHNOLOGY > 1007 Nanotechnology > 100709 Nanomedicine @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 80%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 20%
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