Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors

Han, Shuanglin, Latchoumanin, Olivier, Wu, Guang, Zhou, Gang, Hebbard, Lionel, George, Jacob, and Qiao, Liang (2017) Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors. Cancer Letters, 390. pp. 188-200.

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Chimeric antigen receptors (CARs) are a series of manufactured receptors that have the capacity of binding to specific antigens expressed on surface of tumor cells. A CAR normally has an extracellular antigen recognition domain derived from single variable chain of a monoclonal antibody, a transmembrane domain and an intracellular T cell activation domain. During the last decade, CAR-T cells were demonstrated to possess great therapeutic effects on hematological malignancies. However, strategies using CAR-T cells to treat solid tumors have been hindered by considerable obstacles including "on tissue off target" effects and cytokine storm syndrome. This review will summarize the current understanding of CAR-T cell therapies and briefly describe the currently enrolled clinical trials in solid tumors.

Item ID: 47666
Item Type: Article (Research - C1)
ISSN: 1872-7980
Keywords: chimeric antigen receptor; modified T cells; solid tumor; clinical trials; immunotherapy
Funders: Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney (RWSB), National Health and Medical Research Council (NHMRC), Cancer Council of New South Wales (CCNSW), Cancer Council Queensland (CCQ), James Cook University (JCU)
Projects and Grants: NHMRC Project Grant 1047417, CCNSW Grant APP1070076, CCNSW Grant APP1069733, CCQ Grant APP1123436, JCU Development Grant 94066
Date Deposited: 09 Mar 2017 04:22
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321104 Cancer therapy (excl. chemotherapy and radiation therapy) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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