Zoledronic acid effects wound healing and angiogenesis resulting in BRONJ: an in vitro and in vivo study
Sharma, D., Hamlet, S., Petcu, E., and Ivanovski, S. (2016) Zoledronic acid effects wound healing and angiogenesis resulting in BRONJ: an in vitro and in vivo study. Australian Dental Journal, 61 (4). s29-s29.
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DOI: 10.1111/adj.12482
View at Publisher Website: http://dx.doi.org/10.1111/adj.12482
Abstract
[Extract] Recent literature suggests that suppressed angiogenesis contributes significantly to the pathogenesis of bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) by effecting local vasculature. This in vitro and in vivo study examined the mechanisms by which the anti-angiogenic properties of BP's could lead to the occurrence of BRONJ lesions.