Allergens and molecular diagnostics of shellfish allergy: part 22 of the series Molecular Allergology

Lopata, Andreas L., Kleine-Tebbe, Jörg, and Kamath, Sandip D. (2016) Allergens and molecular diagnostics of shellfish allergy: part 22 of the series Molecular Allergology. Allergo, 25 (7). pp. 210-218.

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Shellfish belongs to "The Big 8" food groups causing allergy, which often does not outgrow during childhood. Shellfish is one of the main food allergens in adults and constitutes a diverse group of species subdivided into crustaceans and mollusks, which seem to include similar but also different allergens. Several pan-allergens are characterized in detail, including tropomyosin and arginine kinase, responsible for clinical cross-reactivity with other invertebrate allergen sources, embracing mites, insects, and parasites. Currently, at least seven different shellfish allergens have been identified, mostly from crustaceans. However, only three recombinant allergens are available for IgE-based routine diagnostic, including tropomyosin, arginine kinase, and sarcoplasmic Ca2+-binding protein. Other allergens include myosin light chain, troponin C, triosephosphate isomerase, and actin. This review summarizes the current advances on the molecular characterization of shellfish allergens, clinical cross-reactivity, and current diagnostic approaches for the management of this life-threatening disease.

Item ID: 47483
Item Type: Article (Scholarly Work)
ISSN: 2195-6405
Keywords: prawn allergy, shellfish, tropomyosin, crustacean, mollusk, arginine kinase
Date Deposited: 01 Mar 2017 07:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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